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TMEM179 transmembrane protein 179 [ Homo sapiens (human) ]

Gene ID: 388021, updated on 2-Nov-2024

Summary

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Official Symbol
TMEM179provided by HGNC
Official Full Name
transmembrane protein 179provided by HGNC
Primary source
HGNC:HGNC:20137
See related
Ensembl:ENSG00000258986 AllianceGenome:HGNC:20137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf90; TMEM179A
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 3.6), adrenal (RPKM 2.8) and 1 other tissue See more
Orthologs
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Genomic context

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See TMEM179 in Genome Data Viewer
Location:
14q32.33
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (104590864..104604772, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (98833645..98847553, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105057201..105071109, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903395 Neighboring gene MPRA-validated peak2256 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105029496-105030057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105030714-105031460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105031461-105032205 Neighboring gene MPRA-validated peak2258 silencer Neighboring gene chromosome 14 open reading frame 180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105053553-105054112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105054113-105054670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6187 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:105119263-105119764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105122182-105122682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105122683-105123183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105125610-105126204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105126205-105126799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105128863-105129362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105131825-105132587 Neighboring gene long intergenic non-protein coding RNA 2280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105143259-105143816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105143817-105144373 Neighboring gene microRNA 4710

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NAC antagonizes arsenic-induced neurotoxicity through TMEM179 by inhibiting oxidative stress in Oli-neu cells. He Z, et al. Ecotoxicol Environ Saf, 2021 Oct 15. PMID 34332247
  2. The DNA sequence and analysis of human chromosome 14. Heilig R, et al. Nature, 2003 Feb 6. PMID 12508121
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Clone Names

  • FLJ42486

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 179
Names
transmembrane protein 179A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286389.2 → NP_001273318.1  transmembrane protein 179 isoform 1

    See identical proteins and their annotated locations for NP_001273318.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK124477, AW026835, BX927359
    Consensus CDS
    CCDS66723.1
    UniProtKB/Swiss-Prot
    Q6ZVK1
    Related
    ENSP00000450958.1, ENST00000556573.6

  2. NM_001286390.2 → NP_001273319.1  transmembrane protein 179 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AI299168, AK124477, AW026835, BX927359
    Consensus CDS
    CCDS73688.1
    UniProtKB/TrEMBL
    A0A087X0S3, A0A0G2JNH9
    Related
    ENSP00000483627.1, ENST00000615704.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    104590864..104604772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536745.3 → XP_011535047.1  transmembrane protein 179 isoform X2

    See identical proteins and their annotated locations for XP_011535047.1

  2. XM_011536750.2 → XP_011535052.1  transmembrane protein 179 isoform X3

    See identical proteins and their annotated locations for XP_011535052.1

  3. XM_024449578.2 → XP_024305346.1  transmembrane protein 179 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JNH9
    Related
    ENSP00000397763.2, ENST00000415614.6

RNA

  1. XR_002957551.2 RNA Sequence

  2. XR_007064011.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187599.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    148687..162595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328948.1 → XP_054184923.1  transmembrane protein 179 isoform X2

  2. XM_054328950.1 → XP_054184925.1  transmembrane protein 179 isoform X3

  3. XM_054328949.1 → XP_054184924.1  transmembrane protein 179 isoform X2

  4. XM_054328951.1 → XP_054184926.1  transmembrane protein 179 isoform X3

  5. XM_054328947.1 → XP_054184922.1  transmembrane protein 179 isoform X1

RNA

  1. XR_008485614.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    98833645..98847553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376026.1 → XP_054232001.1  transmembrane protein 179 isoform X2

  2. XM_054376027.1 → XP_054232002.1  transmembrane protein 179 isoform X2

  3. XM_054376028.1 → XP_054232003.1  transmembrane protein 179 isoform X3

  4. XM_054376025.1 → XP_054232000.1  transmembrane protein 179 isoform X1

RNA

  1. XR_008488867.1 RNA Sequence

  2. XR_008488868.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207379.1: Suppressed sequence

    Description
    NM_207379.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZVK1.2 GenPept UniProtKB/Swiss-Prot:Q6ZVK1

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