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ZNF470 zinc finger protein 470 [ Homo sapiens (human) ]

Gene ID: 388566, updated on 3-Nov-2024

Summary

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Official Symbol
ZNF470provided by HGNC
Official Full Name
zinc finger protein 470provided by HGNC
Primary source
HGNC:HGNC:22220
See related
Ensembl:ENSG00000197016 MIM:620441; AllianceGenome:HGNC:22220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CZF-1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nuclear body. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 2.0), testis (RPKM 1.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF470 in Genome Data Viewer
Location:
19q13.43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56567468..56582894)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59661809..59677296)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57078837..57094262)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 471 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:57037017-57038216 Neighboring gene ZFP28 divergent transcript Neighboring gene ZFP28 zinc finger protein Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:57058653-57059852 Neighboring gene ZNF470 divergent transcript Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:57065620-57066819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15122 Neighboring gene uncharacterized LOC124904777 Neighboring gene sialic acid binding Ig like lectin 31, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization and chondrocyte differentiation stage-specific expression of KRAB zinc-finger protein gene ZNF470. Hering TM, et al. Exp Cell Res, 2004 Sep 10. PMID 15302581
  2. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
  3. LINKIN, a new transmembrane protein necessary for cell adhesion. Kato M, et al. Elife, 2014 Dec 1. PMID 25437307, Free PMC Article
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. Comuzzie AG, et al. PLoS One, 2012. PMID 23251661, Free PMC Article
  5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26175, FLJ26846

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 470
Names
chondrogenesis zinc finger protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001668.4 → NP_001001668.3  zinc finger protein 470

    See identical proteins and their annotated locations for NP_001001668.3

    Status: VALIDATED

    Source sequence(s)
    AA977233, AC007228, AK129686, AY484591, DA412738
    Consensus CDS
    CCDS33122.1
    UniProtKB/Swiss-Prot
    A8MTW0, B9EGU1, Q6ECI4, Q6ZPA1, Q9Y2N9
    Related
    ENSP00000333223.7, ENST00000330619.13
    Conserved Domains (5) summary
    smart00349
    Location:23 → 83
    KRAB; krueppel associated box
    COG5048
    Location:254 → 669
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:258 → 278
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:23 → 62
    KRAB; KRAB box
    pfam13465
    Location:523 → 548
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    56567468..56582894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438804.1 → XP_047294760.1  zinc finger protein 470 isoform X1

    UniProtKB/Swiss-Prot
    A8MTW0, B9EGU1, Q6ECI4, Q6ZPA1, Q9Y2N9

  2. XM_047438805.1 → XP_047294761.1  zinc finger protein 470 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    59661809..59677296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320970.1 → XP_054176945.1  zinc finger protein 470 isoform X1

  2. XM_054320971.1 → XP_054176946.1  zinc finger protein 470 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ECI4.3 GenPept UniProtKB/Swiss-Prot:Q6ECI4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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