Mcad Medium-chain acyl-CoA dehydrogenase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mcadprovided by FlyBase
Official Full Name: Medium-chain acyl-CoA dehydrogenaseprovided by FlyBase
Primary source: FLYBASE:FBgn0035811
Locus tag: Dmel_CG12262
See related: AllianceGenome:FB:FBgn0035811
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ACAD; CG 12262; CG12262; Dmel\CG12262; mcad; MCAD
Summary: Enables medium-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation and medium-chain fatty acid catabolic process. Located in cytosol and mitochondrion. Is expressed in several structures, including epithelium; germline cell; gut section; mesoderm; and visceral mesoderm derivative. Used to study medium chain acyl-CoA dehydrogenase deficiency. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 66A10-66A10; 3-21 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (7719350..7721472)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (7712450..7714572)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PINK1 mediates the phosphorylation of MCAD, a mitochondrial matrix protein critical to fatty acid metabolism.
Title: Phosphorylation of MCAD selectively rescues PINK1 deficiencies in behavior and metabolism.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables medium-chain fatty acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acyl-CoA dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in medium-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Medium-chain acyl-CoA dehydrogenase

Names: CG12262-PA; Mcad-PA; acyl-CoA dehdrogenase; medium chain acyl-CoA dehydrogenase; medium-chain acyl-coenzyme A dehydrogenase; probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial

NP_648149.1

EC 1.3.-.-

EC 1.3.8.7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

7719350..7721472

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_139892.3 → NP_648149.1 Medium-chain acyl-CoA dehydrogenase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648149.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VSA3

UniProtKB/TrEMBL

G3KKP7

Related

FBpp0076520

Conserved Domains (2) summary

cd01157
Location:37 → 414

MCAD; Medium chain acyl-CoA dehydrogenase

COG1960
Location:35 → 411

CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]