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HP4 Heterochromatin protein 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38887, updated on 18-Sep-2024

Summary

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Official Symbol
HP4provided by FlyBase
Official Full Name
Heterochromatin protein 4provided by FlyBase
Primary source
FLYBASE:FBgn0035829
Locus tag
Dmel_CG8044
See related
AllianceGenome:FB:FBgn0035829
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GM01628; CG8044; Dmel\CG8044; hip; Hip
Summary
Involved in chromatin organization. Located in chromocenter; chromosome; and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See HP4 in Genome Data Viewer
Location:
66A21-66A21; 3-21 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7975438..7976154, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7968538..7969254, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ribonuclease X25 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene POP4 ribonuclease P/MRP subunit Neighboring gene nemo Neighboring gene transfer RNA:Alanine-AGC 2-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation. Schwendemann A, et al. Proc Natl Acad Sci U S A, 2008 Jan 8. PMID 18162556, Free PMC Article
  2. Phase separation drives heterochromatin domain formation. Strom AR, et al. Nature, 2017 Jul 13. PMID 28636597, Free PMC Article
  3. The winged-helix transcription factor JUMU regulates development, nucleolus morphology and function, and chromatin organization of Drosophila melanogaster. Hofmann A, et al. Chromosome Res, 2010 Apr. PMID 20213139
  4. Umbrea, a chromo shadow domain protein in Drosophila melanogaster heterochromatin, interacts with Hip, HP1 and HOAP. Joppich C, et al. Chromosome Res, 2009. PMID 19190990, Free PMC Article
  5. The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. McLellan JS, et al. Nature, 2008 Oct 16. PMID 18794898, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hip interacts with Umbrea with functional role in mediating normal telomere behaviour in Drosophila
    Title: Umbrea, a chromo shadow domain protein in Drosophila melanogaster heterochromatin, interacts with Hip, HP1 and HOAP.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromocenter IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heterochromatin protein 4
Names
CG8044-PA
CG8044-PB
HP1-interacting protein
HP4-PA
HP4-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7975438..7976154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139909.3 → NP_648166.2  heterochromatin protein 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648166.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NR9, Q8IQ92
    Related
    FBpp0076479

  2. NM_168247.3 → NP_729314.1  heterochromatin protein 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729314.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3N9, Q9VSC4
    Related
    FBpp0076480
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQ92 Q8IQ92
Q8T3N9 Q8T3N9
Q9VSC4 Q9VSC4

Gene LinkOut

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