U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Exo70 Exocyst 70 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38959, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Exo70provided by FlyBase
Official Full Name
Exocyst 70provided by FlyBase
Primary source
FLYBASE:FBgn0266667
Locus tag
Dmel_CG7127
See related
AllianceGenome:FB:FBgn0266667
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7127; Dmel\CG7127; exo70; Exo70p
Summary
Enables beta-catenin binding activity. Involved in synaptic assembly at neuromuscular junction. Located in terminal bouton. Is expressed in adult head and organism. Orthologous to human EXOC7 (exocyst complex component 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Exo70 in Genome Data Viewer
Location:
66C11-66C11; 3-24 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8411851..8415910)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8404951..8409010)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene monkey king protein Neighboring gene tRNA 2'-phosphotransferase Neighboring gene uncharacterized protein Neighboring gene Outer segment 1 Neighboring gene matrimony Neighboring gene uncharacterized protein Neighboring gene Cbl proto-oncogene Neighboring gene Upstream of N-ras

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3. Chen ZS, et al. Cell Death Dis, 2021 Feb 2. PMID 33542212, Free PMC Article
  2. Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress. Koon AC, et al. J Neurosci, 2018 Sep 12. PMID 30209205, Free PMC Article
  3. A signalling cascade for Ral. Wu Y, et al. Small GTPases, 2022 Jan. PMID 33956571, Free PMC Article
  4. The exocyst complex is required for developmental and regenerative neurite growth in vivo. Swope RD, et al. Dev Biol, 2022 Dec. PMID 36162553, Free PMC Article
  5. PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes. Gass MM, et al. Cell Mol Life Sci, 2022 Apr 18. PMID 35437696, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3.
    Title: A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3.
  2. Exo70 is expressed in both glutamatergic and octopaminergic neurons, and presynaptic Exo70 regulates synaptic outgrowth. exo70 mutants have impaired integral membrane transport to the cell surface at synaptic terminals and block several kinds of induced synaptic growth. Elevated temperature causes severe arborization defects and lethality in exo70 mutants, underpinning the importance of Exo70 in development and adaptation
    Title: Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle docking NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle targeting NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst IEA
Inferred from Electronic Annotation
more info
  
part_of exocyst ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of exocyst NAS
Non-traceable Author Statement
more info
 PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
exocyst 70
Names
CG7127-PA
Exo70 ortholog
Exo70-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8411851..8415910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139965.3 → NP_648222.3  exocyst 70 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648222.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T0E9, Q9VSJ8
    UniProtKB/TrEMBL
    D5AEM7, H1UUN4
    Related
    FBpp0076339
    Conserved Domains (1) summary
    pfam03081
    Location:315 → 686
    Exo70; Exo70 exocyst complex subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VSJ8.2 Q9VSJ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous