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glrx-22 Glutaredoxin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 3896777, updated on 2-Nov-2024

Summary

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Official Symbol
glrx-22
Official Full Name
Glutaredoxin domain-containing protein
Primary source
WormBase:WBGene00044608
Locus tag
CELE_C07G1.8
See related
AllianceGenome:WB:WBGene00044608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein-disulfide reductase activity. Predicted to be active in mitochondrion. Orthologous to human GLRX2 (glutaredoxin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See glrx-22 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (8200604..8201233, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cyclin-dependent kinase 17 Neighboring gene ncRNA Neighboring gene CRIB domain-containing protein Neighboring gene ncRNA Neighboring gene Hepatocyte growth factor-regulated tyrosine kinase substrate Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Redox properties and evolution of human glutaredoxins. Sagemark J, et al. Proteins, 2007 Sep 1. PMID 17546662
  2. The Redox System in C. elegans, a Phylogenetic Approach. Johnston AD, et al. J Toxicol, 2012. PMID 22899914, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Glutaredoxin domain-containing protein
NP_001033391.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8200604..8201233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001038302.2 → NP_001033391.1  Glutaredoxin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001033391.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3Y400
    Conserved Domains (1) summary
    cd02066
    Location:29 → 104
    GRX_family; Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide ...
Nucleotide Protein
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