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rft-1 Riboflavin transporter rft-1 [ Caenorhabditis elegans ]

Gene ID: 3896860, updated on 2-Nov-2024

Summary

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Official Symbol
rft-1
Official Full Name
Riboflavin transporter rft-1
Primary source
WormBase:WBGene00044637
Locus tag
CELE_Y47D7A.16
See related
AllianceGenome:WB:WBGene00044637
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables riboflavin transmembrane transporter activity. Involved in embryo development. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Brown-Vialetto-Van Laere syndrome 1; Brown-Vialetto-Van Laere syndrome 2; Fazio-Londe disease; and riboflavin deficiency. Orthologous to several human genes including SLC52A2 (solute carrier family 52 member 2) and SLC52A3 (solute carrier family 52 member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rft-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (4438932..4443223, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Glycine Rich Secreted Protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Riboflavin transporter;Riboflavin transporter rft-2 Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Riboflavin transporter-2 (rft-2) of Caenorhabditis elegans: Adaptive and developmental regulation. Gandhimathi K, et al. J Biosci, 2015 Jun. PMID 25963255
  2. Riboflavin depletion promotes longevity and metabolic hormesis in Caenorhabditis elegans. Yerevanian A, et al. Aging Cell, 2022 Nov. PMID 36181246, Free PMC Article
  3. Identification and functional characterization of the Caenorhabditis elegans riboflavin transporters rft-1 and rft-2. Biswas A, et al. PLoS One, 2013. PMID 23483992, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables riboflavin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables riboflavin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables riboflavin transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in riboflavin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in riboflavin transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Riboflavin transporter rft-1
NP_001033515.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    4438932..4443223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001038426.4 → NP_001033515.2  Riboflavin transporter rft-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001033515.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3LFN0
    Conserved Domains (1) summary
    pfam06237
    Location:271 → 356
    DUF1011; Protein of unknown function (DUF1011)

RNA

  1. NR_138524.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3LFN0.2

Gene LinkOut

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