OR52A5 olfactory receptor family 52 subfamily A member 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OR52A5provided by HGNC
Official Full Name: olfactory receptor family 52 subfamily A member 5provided by HGNC
Primary source: HGNC:HGNC:19580
See related: Ensembl:ENSG00000171944 AllianceGenome:HGNC:19580
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OR11-33
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs: all
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Genomic context

Location:: 11p15.4

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (5128776..5138356, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (5188115..5197698, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (5150006..5159586, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

REN96993 (e-PCR)
- UniSTS:421791

REN96994 (e-PCR)
- UniSTS:421792

REN96995 (e-PCR)
- UniSTS:421793

REN96996 (e-PCR)
- UniSTS:421794

REN96997 (e-PCR)
- UniSTS:421795

REN96998 (e-PCR)
- UniSTS:421796

REN96999 (e-PCR)
- UniSTS:421797

REN97000 (e-PCR)
- UniSTS:421798

REN97001 (e-PCR)
- UniSTS:421799

REN97002 (e-PCR)
- UniSTS:421800

REN97003 (e-PCR)
- UniSTS:421801

REN97004 (e-PCR)
- UniSTS:421802

REN97005 (e-PCR)
- UniSTS:421803

REN97006 (e-PCR)
- UniSTS:421804

ECD17174 (e-PCR)
- UniSTS:298187

ECD03809 (e-PCR)
- UniSTS:284889

ECD16164 (e-PCR)
- UniSTS:297179

ECD24422 (e-PCR)
- UniSTS:305406

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of smell	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of smell	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: olfactory receptor 52A5

Names: odorant receptor HOR3'beta5; olfactory receptor OR11-33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005160.3 → NP_001005160.1 olfactory receptor 52A5

See identical proteins and their annotated locations for NP_001005160.1

Status: VALIDATED

Source sequence(s)

AC129505

Consensus CDS

CCDS31373.1

UniProtKB/Swiss-Prot

Q9H2C5

UniProtKB/TrEMBL

A0A126GWD2

Related

ENSP00000303469.1, ENST00000307388.2

Conserved Domains (2) summary

pfam00001
Location:43 → 295

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:33 → 313

7tm_4; Olfactory receptor