OR52H1 olfactory receptor family 52 subfamily H member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OR52H1provided by HGNC
Official Full Name: olfactory receptor family 52 subfamily H member 1provided by HGNC
Primary source: HGNC:HGNC:15218
See related: Ensembl:ENSG00000181616 AllianceGenome:HGNC:15218
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OR11-41; OR11-45
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs: mouse all
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Genomic context

Location:: 11p15.4

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (5544561..5548540, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (5603936..5607923, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (5565791..5569770, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

REN98631 (e-PCR)
- UniSTS:423428

REN98632 (e-PCR)
- UniSTS:423429

REN98633 (e-PCR)
- UniSTS:423430

REN98634 (e-PCR)
- UniSTS:423431

REN98635 (e-PCR)
- UniSTS:423432

REN98636 (e-PCR)
- UniSTS:423433

REN98637 (e-PCR)
- UniSTS:423434

REN98638 (e-PCR)
- UniSTS:423435

REN98639 (e-PCR)
- UniSTS:423436

REN98640 (e-PCR)
- UniSTS:423437

REN98641 (e-PCR)
- UniSTS:423438

REN98642 (e-PCR)
- UniSTS:423439

REN98643 (e-PCR)
- UniSTS:423440

ECD17264 (e-PCR)
- UniSTS:298277

ECD14727 (e-PCR)
- UniSTS:295747

OR52H1__5884 (e-PCR)
- UniSTS:463718

stSG611049 (e-PCR)
- UniSTS:449157

ECD07155 (e-PCR)
- UniSTS:288212

ECD07197 (e-PCR)
- UniSTS:288254

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of smell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: olfactory receptor 52H1

Names: olfactory receptor OR11-41 pseudogene; olfactory receptor OR11-45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005289.5 → NP_001005289.2 olfactory receptor 52H1

Status: VALIDATED

Source sequence(s)

AC087380

Consensus CDS

CCDS31386.2

UniProtKB/Swiss-Prot

B9EH26, Q6IF79, Q8NGJ2

UniProtKB/TrEMBL

A0A126GWQ6

Related

ENSP00000326259.5, ENST00000322653.7

Conserved Domains (1) summary

cd15221
Location:27 → 301

7tmA_OR52B-like; olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors