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OR52N5 olfactory receptor family 52 subfamily N member 5 [ Homo sapiens (human) ]

Gene ID: 390075, updated on 28-Oct-2024

Summary

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Official Symbol
OR52N5provided by HGNC
Official Full Name
olfactory receptor family 52 subfamily N member 5provided by HGNC
Primary source
HGNC:HGNC:15231
See related
Ensembl:ENSG00000181009 AllianceGenome:HGNC:15231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR11-62; OR52N5Q
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

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See OR52N5 in Genome Data Viewer
Location:
11p15.4
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (5776165..5783355, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (5833970..5841160, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5797395..5804585, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily N member 4 Neighboring gene olfactory receptor family 56 subfamily B member 1 Neighboring gene olfactory receptor family 56 subfamily B member 2 Neighboring gene olfactory receptor family 52 subfamily N member 1 Neighboring gene olfactory receptor family 52 subfamily N member 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  2. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactory receptor 52N5
Names
olfactory receptor OR11-62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001922.2 → NP_001001922.2  olfactory receptor 52N5

    See identical proteins and their annotated locations for NP_001001922.2

    Status: VALIDATED

    Source sequence(s)
    BC136981
    Consensus CDS
    CCDS31397.1
    UniProtKB/Swiss-Prot
    B9EH12, Q6IFG2, Q8NH56
    UniProtKB/TrEMBL
    A0A126GVK9
    Related
    ENSP00000322866.2, ENST00000317093.2
    Conserved Domains (2) summary
    cd14964
    Location:34 → 60
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 309
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001385662.1 → NP_001372591.1  olfactory receptor 52N5

    Status: VALIDATED

    Source sequence(s)
    AC131574
    Consensus CDS
    CCDS31397.1
    UniProtKB/Swiss-Prot
    B9EH12, Q6IFG2, Q8NH56
    UniProtKB/TrEMBL
    A0A126GVK9
    Related
    ENSP00000493190.1, ENST00000641181.1
    Conserved Domains (2) summary
    cd14964
    Location:34 → 60
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 309
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    5776165..5783355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    5833970..5841160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NH56.2 GenPept UniProtKB/Swiss-Prot:Q8NH56

Gene LinkOut

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