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OR5B12 olfactory receptor family 5 subfamily B member 12 [ Homo sapiens (human) ]

Gene ID: 390191, updated on 2-Nov-2024

Summary

Official Symbol
OR5B12provided by HGNC
Official Full Name
olfactory receptor family 5 subfamily B member 12provided by HGNC
Primary source
HGNC:HGNC:15432
See related
Ensembl:ENSG00000172362 AllianceGenome:HGNC:15432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR5B16; OST743; OR5B12P; OR11-241
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR5B12 in Genome Data Viewer
Location:
11q12.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (58438994..58442236, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (58388900..58392142, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58206467..58209709, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily B member 3 Neighboring gene olfactory receptor family 5 subfamily B member 2 Neighboring gene uncharacterized LOC105369313 Neighboring gene olfactory receptor family 5 subfamily B member 21 Neighboring gene Sharpr-MPRA regulatory region 15251 Neighboring gene leupaxin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4737 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58345528-58346220

Genomic regions, transcripts, and products

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
olfactory receptor 5B12
Names
olfactory receptor 5B16
olfactory receptor OR11-241
olfactory receptor, family 5, subfamily B, member 12 pseudogene
olfactory receptor, family 5, subfamily B, member 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004733.3NP_001004733.1  olfactory receptor 5B12

    See identical proteins and their annotated locations for NP_001004733.1

    Status: VALIDATED

    Source sequence(s)
    AP002345
    Consensus CDS
    CCDS31551.1
    UniProtKB/Swiss-Prot
    B2RNL2, Q6IEV5, Q96R08
    UniProtKB/TrEMBL
    A0A126GWS6
    Related
    ENSP00000493263.1, ENST00000641921.2
    Conserved Domains (2) summary
    pfam00001
    Location:39288
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:29301
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    58438994..58442236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    58388900..58392142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)