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LAMA3 laminin subunit alpha 3 [ Homo sapiens (human) ]

Gene ID: 3909, updated on 2-Nov-2024

Summary

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Official Symbol
LAMA3provided by HGNC
Official Full Name
laminin subunit alpha 3provided by HGNC
Primary source
HGNC:HGNC:6483
See related
Ensembl:ENSG00000053747 MIM:600805; AllianceGenome:HGNC:6483
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E170; LOCS; BM600; JEB2A; JEB2B; JEB2C; LAMNA
Summary
The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Broad expression in lung (RPKM 10.8), stomach (RPKM 10.0) and 18 other tissues See more
Orthologs
mouse all
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Genomic context

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See LAMA3 in Genome Data Viewer
Location:
18q11.2
Exon count:
79
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (23689453..23955066)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (23883722..24149324)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (21269417..21535030)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 29 Neighboring gene Sharpr-MPRA regulatory region 8852 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:21268776-21269325 Neighboring gene ribosomal protein S10 pseudogene 27 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:21299932-21300432 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:21300433-21300933 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:21305921-21306891 Neighboring gene ribosomal protein L23a pseudogene 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:21427116-21427961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13165 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:21452354-21453553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:21531393-21532253 Neighboring gene MPRA-validated peak3071 silencer Neighboring gene long intergenic non-protein coding RNA 2958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9361 Neighboring gene TTC39C antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9363 Neighboring gene tetratricopeptide repeat domain 39C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Aberrant promoter methylation and silencing of laminin-5-encoding genes in breast carcinoma. Sathyanarayana UG, et al. Clin Cancer Res, 2003 Dec 15. PMID 14695139
  2. Association of variation in the LAMA3 gene, encoding the alpha-chain of laminin 5, with atopic dermatitis in a German case-control cohort. Stemmler S, et al. BMC Dermatol, 2014 Nov 3. PMID 25363238, Free PMC Article
  3. Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis. Morales-Nebreda LI, et al. Am J Respir Cell Mol Biol, 2015 Apr. PMID 25188360, Free PMC Article
  4. Biological network inferences for a protection mechanism against familial Creutzfeldt-Jakob disease with E200K pathogenic mutation. Lee SM, et al. BMC Med Genomics, 2014 Aug 22. PMID 25149502, Free PMC Article
  5. A new homozygous nonsense mutation in LAMA3A underlying laryngo-onycho-cutaneous syndrome. Barzegar M, et al. Br J Dermatol, 2013 Dec. PMID 23869449

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Clinical and bioinformatics analysis of the relationship between LAMA3 DNA methylation expression and platinum resistance and prognosis in epithelial ovarian cancer].
    Title: [Clinical and bioinformatics analysis of the relationship between LAMA3 DNA methylation expression and platinum resistance and prognosis in epithelial ovarian cancer].
  2. Correlation of laminin subunit alpha 3 expression in pancreatic ductal adenocarcinoma with tumor liver metastasis and survival.
    Title: Correlation of laminin subunit alpha 3 expression in pancreatic ductal adenocarcinoma with tumor liver metastasis and survival.
  3. Lentiviral expression of wild-type LAMA3A restores cell adhesion in airway basal cells from children with epidermolysis bullosa.
    Title: Lentiviral expression of wild-type LAMA3A restores cell adhesion in airway basal cells from children with epidermolysis bullosa.
  4. LAMA3 Promotes Tumorigenesis of Oral Squamous Cell Carcinoma by METTL3-Mediated N6-Methyladenosine Modification.
    Title: LAMA3 Promotes Tumorigenesis of Oral Squamous Cell Carcinoma by METTL3-Mediated N6-Methyladenosine Modification.
  5. Phenotypic variability in LAMA3-associated amelogenesis imperfecta.
    Title: Phenotypic variability in LAMA3-associated amelogenesis imperfecta.
  6. LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3.
    Title: LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3.
  7. Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families.
    Title: Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families.
  8. Gene expression profiling of laminin alpha3-blocked keratinocytes reveals an immune-independent mechanism of blistering.
    Title: Gene expression profiling of laminin α3-blocked keratinocytes reveals an immune-independent mechanism of blistering.
  9. High expression of LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis.
    Title: High expression of LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis.
  10. LAMA3 DNA methylation and transcriptome changes associated with chemotherapy resistance in ovarian cancer.
    Title: LAMA3 DNA methylation and transcriptome changes associated with chemotherapy resistance in ovarian cancer.
Submit: New GeneRIF Correction See all GeneRIFs (66)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
EBI GWAS Catalog
Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins PubMed
Tat tat Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution PubMed
tat HIV-1 Tat enhances adhesion of human U937 monocyte-like cells to proteins of the extracellular matrix, such as collagen IV, laminin, and ECM1 PubMed
tat HIV-1 Tat upregulates the expression of extracellular matrix proteins, including the major basement membrane protein laminin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables structural molecule activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in endodermal cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in epidermis development TAS
Traceable Author Statement
more info
 PubMed 
involved_in hemidesmosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in basement membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in hemidesmosome IEA
Inferred from Electronic Annotation
more info
  
part_of laminin-3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of laminin-5 complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
laminin subunit alpha-3
Names
BM600 150kD subunit
LAM3, alpha-3 subunit
epiligrin 170 kda subunit
epiligrin alpha 3 subunit
kalinin 165kD subunit
kalinin subunit alpha
laminin 5, alpha-3 subunit
laminin A3
laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin)
laminin-5 alpha 3 chain
laminin-5 subunit alpha
laminin-6 subunit alpha
laminin-7 subunit alpha
nicein 150kD subunit
nicein subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007853.2 RefSeqGene

    Range
    4856..270469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000227.6 → NP_000218.3  laminin subunit alpha-3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_000218.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a distinct 5' UTR, lacks exons in the 5' coding region, and uses an alternate start codon compared to variant 1. The encoded isoform (2, also known as alpha3a) has a distinct and shorter N-terminus than isoform 1. Variants 2 and 4 encode "a" isoforms.
    Source sequence(s)
    AA001432, AC010754, AY327115, DA862923, KF456351, L34155
    Consensus CDS
    CCDS11880.1
    UniProtKB/TrEMBL
    A0A0A6YYF2, Q59HA6
    Related
    ENSP00000269217.5, ENST00000269217.11
    Conserved Domains (7) summary
    COG0840
    Location:399 → 779
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    cd00055
    Location:77 → 123
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:1549 → 1700
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:125 → 175
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:236 → 495
    Laminin_I; Laminin Domain I
    pfam06009
    Location:679 → 807
    Laminin_II; Laminin Domain II
    cl21509
    Location:483 → 647
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

  2. NM_001127717.4 → NP_001121189.2  laminin subunit alpha-3 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also called b2) lacks an in-frame exon in the coding region compared to variant 1. It encodes isoform 3 (also known as alpha3b2), which is shorter than isoform 1. Variants 1 and 3 encode "b" isoforms.
    Source sequence(s)
    AA001432, AC010754, AK096422, AY327116, KF456351
    Consensus CDS
    CCDS45838.1
    UniProtKB/TrEMBL
    A0A0A0MSA0, B0YJ32
    Related
    ENSP00000382432.2, ENST00000399516.7
    Conserved Domains (9) summary
    smart00136
    Location:46 → 297
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:1514 → 1641
    LamB; Laminin B domain
    smart00282
    Location:2379 → 2514
    LamG; Laminin G domain
    cd00055
    Location:535 → 577
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3102 → 3253
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:1266 → 1314
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:1845 → 2048
    Laminin_I; Laminin Domain I
    pfam06009
    Location:2232 → 2360
    Laminin_II; Laminin Domain II
    cl21509
    Location:2036 → 2200
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

  3. NM_001127718.4 → NP_001121190.2  laminin subunit alpha-3 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001121190.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has a distinct 5' UTR, lacks exons in the 5' coding region, lacks an internal in-frame exon, and uses an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 4 encode "a" isoforms.
    Source sequence(s)
    AA001432, AC010754, AY327114, DA862923, KF456351
    Consensus CDS
    CCDS59307.1
    UniProtKB/TrEMBL
    A0A0A0MTS5, Q59HA6
    Related
    ENSP00000466557.1, ENST00000587184.5
    Conserved Domains (6) summary
    cd00055
    Location:77 → 123
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:1493 → 1644
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:125 → 175
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:236 → 439
    Laminin_I; Laminin Domain I
    pfam06009
    Location:623 → 751
    Laminin_II; Laminin Domain II
    cl21509
    Location:427 → 591
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

  4. NM_001302996.2 → NP_001289925.1  laminin subunit alpha-3 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as LN1) lacks a large portion of the 3' coding region and has a distinct 3' coding region and 3' UTR compared to variant 1. The encoded isoform (5, also known as LaNt alpha31) has a distinct and shorter C-terminus than isoform 1. This variant is supported by experimental data in PMID:19773554.
    Source sequence(s)
    AC067796, AI125611, AK096422, AY327115
    UniProtKB/Swiss-Prot
    Q16787
    Conserved Domains (3) summary
    smart00136
    Location:46 → 297
    LamNT; Laminin N-terminal domain (domain VI)
    cd00055
    Location:299 → 344
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:356 → 423
    Laminin_EGF; Laminin EGF domain

  5. NM_198129.4 → NP_937762.2  laminin subunit alpha-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_937762.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as b1, represents the longest transcript and encodes the longest isoform (1, also known as alpha3B1). Variants 1 and 3 encode "b" isoforms.
    Source sequence(s)
    AB107369, AC010754, AC067796
    Consensus CDS
    CCDS42419.1
    UniProtKB/Swiss-Prot
    B0YJ33, Q13679, Q13680, Q16787, Q6VU67, Q6VU68, Q6VU69, Q76E14, Q96TG0
    UniProtKB/TrEMBL
    B0YJ32
    Related
    ENSP00000324532.8, ENST00000313654.14
    Conserved Domains (9) summary
    smart00136
    Location:46 → 297
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:1514 → 1641
    LamB; Laminin B domain
    smart00282
    Location:2435 → 2570
    LamG; Laminin G domain
    cd00055
    Location:535 → 577
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3158 → 3309
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:1266 → 1314
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:1845 → 2104
    Laminin_I; Laminin Domain I
    pfam06009
    Location:2288 → 2416
    Laminin_II; Laminin Domain II
    cl21509
    Location:2092 → 2256
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RNA

  1. NR_130106.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks multiple 3' exons and uses an alternate 3' terminal exon compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translation start codon results in an open reading frame without a stop codon and renders the transcript a candidate for non-stop decay.
    Source sequence(s)
    AK096422, BC033663, BC093406
    Related
    ENST00000585600.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    23689453..23955066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525978.3 → XP_011524280.1  laminin subunit alpha-3 isoform X1

    UniProtKB/TrEMBL
    B0YJ32
    Conserved Domains (9) summary
    smart00136
    Location:46 → 297
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:1523 → 1650
    LamB; Laminin B domain
    smart00282
    Location:2444 → 2579
    LamG; Laminin G domain
    cd00055
    Location:535 → 577
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3167 → 3318
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:1275 → 1323
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:1854 → 2113
    Laminin_I; Laminin Domain I
    pfam06009
    Location:2297 → 2425
    Laminin_II; Laminin Domain II
    cl21509
    Location:2101 → 2265
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

  2. XM_011525982.3 → XP_011524284.1  laminin subunit alpha-3 isoform X8

    UniProtKB/TrEMBL
    B0YJ32
    Conserved Domains (9) summary
    smart00136
    Location:46 → 297
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:1523 → 1650
    LamB; Laminin B domain
    smart00282
    Location:2345 → 2480
    LamG; Laminin G domain
    cd00055
    Location:535 → 577
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3068 → 3219
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:1275 → 1323
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:1854 → 2113
    Laminin_I; Laminin Domain I
    pfam06009
    Location:2217 → 2326
    Laminin_II; Laminin Domain II
    cl21509
    Location:2066 → 2196
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

  3. XM_011525980.3 → XP_011524282.1  laminin subunit alpha-3 isoform X3

    UniProtKB/TrEMBL
    B0YJ32
    Conserved Domains (9) summary
    smart00136
    Location:46 → 297
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:1517 → 1644
    LamB; Laminin B domain
    smart00282
    Location:2438 → 2573
    LamG; Laminin G domain
    cd00055
    Location:535 → 577
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3161 → 3312
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:1269 → 1317
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:1848 → 2107
    Laminin_I; Laminin Domain I
    pfam06009
    Location:2291 → 2419
    Laminin_II; Laminin Domain II
    cl21509
    Location:2095 → 2259
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

  4. XM_011525979.3 → XP_011524281.1  laminin subunit alpha-3 isoform X2

    UniProtKB/TrEMBL
    B0YJ32
    Conserved Domains (9) summary
    smart00136
    Location:46 → 297
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:1520 → 1647
    LamB; Laminin B domain
    smart00282
    Location:2441 → 2576
    LamG; Laminin G domain
    cd00055
    Location:535 → 577
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3164 → 3315
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:1272 → 1320
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:1851 → 2110
    Laminin_I; Laminin Domain I
    pfam06009
    Location:2294 → 2422
    Laminin_II; Laminin Domain II
    cl21509
    Location:2098 → 2262
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

  5. XM_047437506.1 → XP_047293462.1  laminin subunit alpha-3 isoform X9

  6. XM_011525981.3 → XP_011524283.1  laminin subunit alpha-3 isoform X4

    UniProtKB/TrEMBL
    B0YJ32
    Conserved Domains (9) summary
    smart00136
    Location:46 → 297
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:1479 → 1606
    LamB; Laminin B domain
    smart00282
    Location:2400 → 2535
    LamG; Laminin G domain
    cd00055
    Location:491 → 533
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3123 → 3274
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:1231 → 1279
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:1810 → 2069
    Laminin_I; Laminin Domain I
    pfam06009
    Location:2253 → 2381
    Laminin_II; Laminin Domain II
    cl21509
    Location:2057 → 2221
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

  7. XM_047437503.1 → XP_047293459.1  laminin subunit alpha-3 isoform X5

  8. XM_047437504.1 → XP_047293460.1  laminin subunit alpha-3 isoform X6

  9. XM_047437505.1 → XP_047293461.1  laminin subunit alpha-3 isoform X7

  10. XM_017025743.1 → XP_016881232.1  laminin subunit alpha-3 isoform X10

    UniProtKB/TrEMBL
    A0A3B3ITG1
    Related
    ENSP00000497885.1, ENST00000649721.1

  11. XM_017025744.2 → XP_016881233.1  laminin subunit alpha-3 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    23883722..24149324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318609.1 → XP_054174584.1  laminin subunit alpha-3 isoform X1

  2. XM_054318616.1 → XP_054174591.1  laminin subunit alpha-3 isoform X8

  3. XM_054318611.1 → XP_054174586.1  laminin subunit alpha-3 isoform X3

  4. XM_054318610.1 → XP_054174585.1  laminin subunit alpha-3 isoform X2

  5. XM_054318617.1 → XP_054174592.1  laminin subunit alpha-3 isoform X9

  6. XM_054318612.1 → XP_054174587.1  laminin subunit alpha-3 isoform X4

  7. XM_054318613.1 → XP_054174588.1  laminin subunit alpha-3 isoform X5

  8. XM_054318614.1 → XP_054174589.1  laminin subunit alpha-3 isoform X6

  9. XM_054318615.1 → XP_054174590.1  laminin subunit alpha-3 isoform X7

  10. XM_054318618.1 → XP_054174593.1  laminin subunit alpha-3 isoform X10

  11. XM_054318619.1 → XP_054174594.1  laminin subunit alpha-3 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16787.3 GenPept UniProtKB/Swiss-Prot:Q16787

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