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mycb - MYC proto-oncogene, bHLH transcription factor b

Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Acts upstream of or within definitive hemopoiesis and hematopoietic progenitor cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including caudal vein plexus; intestine; nervous system; presumptive neural retina; and shield. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); prostate cancer (multiple); and urinary bladder cancer. Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

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Species Gene Architecture aa