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INPP5E Inositol polyphosphate 5-phosphatase E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39404, updated on 2-Nov-2024

Summary

Official Symbol
INPP5Eprovided by FlyBase
Official Full Name
Inositol polyphosphate 5-phosphatase Eprovided by FlyBase
Primary source
FLYBASE:FBgn0036273
Locus tag
Dmel_CG10426
See related
AllianceGenome:FB:FBgn0036273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10426; dInpp5e; Dmel\CG10426; Inpp5e; INPPE5; IPP
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in protein localization to cilium and sensory perception of sound. Located in ciliary base. Is expressed in several structures, including eye disc; gland; larval central nervous system; larval peripheral nervous system; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 1. Orthologous to human INPP5E (inositol polyphosphate-5-phosphatase E). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See INPP5E in Genome Data Viewer
Location:
69A5-69A5; 3-38 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12277655..12281476)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12270755..12274576)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Porphobilinogen synthase Neighboring gene Spermine synthase Neighboring gene long non-coding RNA:CR46241 Neighboring gene long non-coding RNA:CR45658

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to cilium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sound IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in ciliary base IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ciliary base IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
inositol polyphosphate 5-phosphatase E
Names
CG10426-PA
CG10426-PB
INPP5E-PA
INPP5E-PB
pharbin-like
NP_001261753.1
NP_648566.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12277655..12281476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140309.2NP_648566.1  inositol polyphosphate 5-phosphatase E, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648566.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTW2
    Related
    FBpp0075739
    Conserved Domains (1) summary
    cl00490
    Location:387703
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  2. NM_001274824.1NP_001261753.1  inositol polyphosphate 5-phosphatase E, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261753.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTW2
    Conserved Domains (1) summary
    cl00490
    Location:387703
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily