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PCLO piccolo presynaptic cytomatrix protein [ Gallus gallus (chicken) ]

Gene ID: 395319, updated on 17-Aug-2024

Summary

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Official Symbol
PCLOprovided by CGNC
Official Full Name
piccolo presynaptic cytomatrix proteinprovided by CGNC
Primary source
CGNC:49263
See related
Ensembl:ENSGALG00010006261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ACZ
Orthologs
human mouse all
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Genomic context

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See PCLO in Genome Data Viewer
Location:
chromosome: 1
Exon count:
27
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (9939054..10269735)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (10070173..10398099)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene semaphorin 3A Neighboring gene semaphorin 3E Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene uncharacterized LOC112532984 Neighboring gene uncharacterized LOC112532986 Neighboring gene uncharacterized LOC107057089

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin. Wang X, et al. J Cell Biol, 1999 Oct 4. PMID 10508862, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural constituent of presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in presynaptic active zone assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton of presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein piccolo
Names
aczonin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396406.1 → NP_001383335.1  protein piccolo

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012, Y19187
    UniProtKB/TrEMBL
    A0A8V0XXL2
    Related
    ENSGALP00010008778.1, ENSGALT00010014914.1
    Conserved Domains (8) summary
    PTZ00121
    Location:1023 → 1451
    PTZ00121; MAEBL; Provisional
    cd04031
    Location:4691 → 4825
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4507 → 4585
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1383 → 1636
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
    cl14603
    Location:5067 → 5192
    C2; C2 domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    9939054..10269735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040665411.2 → XP_040521345.1  protein piccolo isoform X1

    UniProtKB/TrEMBL
    A0A8V0XXL2
    Conserved Domains (8) summary
    PTZ00121
    Location:1023 → 1451
    PTZ00121; MAEBL; Provisional
    cd04031
    Location:4691 → 4825
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4507 → 4585
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1383 → 1636
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
    cl14603
    Location:5066 → 5191
    C2; C2 domain

  2. XM_040665421.2 → XP_040521355.1  protein piccolo isoform X3

    UniProtKB/TrEMBL
    A0A8V0XXL2
    Conserved Domains (8) summary
    PTZ00121
    Location:1023 → 1451
    PTZ00121; MAEBL; Provisional
    cd04031
    Location:4691 → 4825
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4507 → 4585
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1383 → 1636
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
    cl14603
    Location:5031 → 5156
    C2; C2 domain

  3. XM_040665430.2 → XP_040521364.1  protein piccolo isoform X4

    UniProtKB/TrEMBL
    A0A8V0XQ04, A0A8V0XXL2
    Related
    ENSGALP00010008781.1, ENSGALT00010014920.1
    Conserved Domains (8) summary
    PTZ00121
    Location:1023 → 1451
    PTZ00121; MAEBL; Provisional
    cd04031
    Location:4691 → 4825
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4507 → 4585
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1383 → 1636
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
    cl14603
    Location:5006 → 5131
    C2; C2 domain

  4. XM_040665417.2 → XP_040521351.1  protein piccolo isoform X2

    UniProtKB/TrEMBL
    A0A8V0XXL2
    Conserved Domains (8) summary
    PTZ00121
    Location:1023 → 1451
    PTZ00121; MAEBL; Provisional
    cd04031
    Location:4691 → 4816
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4507 → 4585
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1383 → 1636
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
    cl14603
    Location:5058 → 5183
    C2; C2 domain

  5. XM_040665439.2 → XP_040521373.1  protein piccolo isoform X5

    UniProtKB/TrEMBL
    A0A8V0XXL2, A0A8V0XXL7
    Related
    ENSGALP00010008783.1, ENSGALT00010014924.1
    Conserved Domains (8) summary
    PTZ00121
    Location:1023 → 1451
    PTZ00121; MAEBL; Provisional
    cd04031
    Location:4691 → 4816
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4507 → 4585
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1383 → 1636
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
    cl14603
    Location:4997 → 5122
    C2; C2 domain

  6. XM_040665448.2 → XP_040521382.1  protein piccolo isoform X6

    UniProtKB/TrEMBL
    A0A8V0XXL2
    Conserved Domains (6) summary
    PTZ00121
    Location:1023 → 1451
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4507 → 4585
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1383 → 1636
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo

  7. XM_040665459.2 → XP_040521393.1  protein piccolo isoform X7

    UniProtKB/TrEMBL
    A0A8V0XXL2
    Conserved Domains (6) summary
    PTZ00121
    Location:1023 → 1451
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4507 → 4579
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1383 → 1636
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    10070173..10398099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040657390.2 → XP_040513324.1  protein piccolo isoform X1

    UniProtKB/TrEMBL
    A0A8V0XXL2
    Conserved Domains (8) summary
    PTZ00121
    Location:1023 → 1450
    PTZ00121; MAEBL; Provisional
    cd04031
    Location:4690 → 4824
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4506 → 4584
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1382 → 1635
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
    cl14603
    Location:5065 → 5190
    C2; C2 domain

  2. XM_040657392.2 → XP_040513326.1  protein piccolo isoform X3

    UniProtKB/TrEMBL
    A0A8V0XXL2
    Conserved Domains (8) summary
    PTZ00121
    Location:1023 → 1450
    PTZ00121; MAEBL; Provisional
    cd04031
    Location:4690 → 4824
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4506 → 4584
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1382 → 1635
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
    cl14603
    Location:5030 → 5155
    C2; C2 domain

  3. XM_040657393.2 → XP_040513327.1  protein piccolo isoform X4

    UniProtKB/TrEMBL
    A0A8V0XXL2
    Conserved Domains (8) summary
    PTZ00121
    Location:1023 → 1450
    PTZ00121; MAEBL; Provisional
    cd04031
    Location:4690 → 4824
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4506 → 4584
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1382 → 1635
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
    cl14603
    Location:5005 → 5130
    C2; C2 domain

  4. XM_040657391.2 → XP_040513325.1  protein piccolo isoform X2

    UniProtKB/TrEMBL
    A0A8V0XXL2
    Conserved Domains (8) summary
    PTZ00121
    Location:1023 → 1450
    PTZ00121; MAEBL; Provisional
    cd04031
    Location:4690 → 4815
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4506 → 4584
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1382 → 1635
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
    cl14603
    Location:5057 → 5182
    C2; C2 domain

  5. XM_040657394.2 → XP_040513328.1  protein piccolo isoform X5

    UniProtKB/TrEMBL
    A0A8V0XXL2
    Conserved Domains (8) summary
    PTZ00121
    Location:1023 → 1450
    PTZ00121; MAEBL; Provisional
    cd04031
    Location:4690 → 4815
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4506 → 4584
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1382 → 1635
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
    cl14603
    Location:4996 → 5121
    C2; C2 domain

  6. XM_040657395.2 → XP_040513329.1  protein piccolo isoform X6

    UniProtKB/TrEMBL
    A0A8V0XXL2
    Conserved Domains (6) summary
    PTZ00121
    Location:1023 → 1450
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4506 → 4584
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1382 → 1635
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo

  7. XM_040657396.2 → XP_040513330.1  protein piccolo isoform X7

    UniProtKB/TrEMBL
    A0A8V0XXL2
    Conserved Domains (6) summary
    PTZ00121
    Location:1023 → 1450
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:232 → 862
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4506 → 4578
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00108
    Location:1382 → 1635
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd15774
    Location:446 → 507
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    cd15776
    Location:914 → 977
    FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9PU36.1 GenPept UniProtKB/Swiss-Prot:Q9PU36

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