TNF tumor necrosis factor [Sus scrofa (pig)] - Gene

Summary

Official Symbol: TNFprovided by VGNC
Official Full Name: tumor necrosis factorprovided by VGNC
Primary source: VGNC:VGNC:94249
See related: Ensembl:ENSSSCG00000060860
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: TNFa; TNFSF2
Expression: Biased expression in spleen (RPKM 8.4), lung (RPKM 3.7) and 1 other tissue See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 7

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	7	NC_010449.5 (23699635..23702393)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	7	NC_010449.4 (27549619..27552377, complement)

Chromosome 7 - NC_010449.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1.
Title: Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1.
The present study showed that TNF-alpha, which was secreted by the tracheal epithelial cells when they were stimulated with several swine pathogens, damaged tight junction proteins and disrupted the epithelial barrier of a pig tracheal epithelial cell model.
Title: TNF-α disrupts the integrity of the porcine respiratory epithelial barrier.
Mechanistically, Porcine productive and respiratory syndrome virus induced an elevated level of tumor necrosis factor (TNF-alpha), through the nuclear factor kappaB (NF-kappaB) signaling pathway to inhibit the replication of classical swine fever virus -C in vitro.
Title: TNF-α induced by porcine reproductive and respiratory syndrome virus inhibits the replication of classical swine fever virus C-strain.
this study shows of TNF-alpha to the form of post-traumatic osteoarthritis induced by "idealized" anterior cruciate ligament reconstruction in a porcine model
Title: Contribution of IL-1β, 6 and TNF-α to the form of post-traumatic osteoarthritis induced by "idealized" anterior cruciate ligament reconstruction in a porcine model.
these findings provide the direct evidence that ADAM17 cleaves porcine TNFalpha, which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy
Title: Production of porcine TNFα by ADAM17-mediated cleavage negatively regulates porcine reproductive and respiratory syndrome virus infection.
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB/ TNF-alpha pathway in cardiomyocytes.
Title: Effects of Trimetazidine on PDCD4/NF-κB/TNF-α Pathway in Coronary Microembolization.
TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 and essential retinal pigment epithelium genes.
Title: Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-α.
TNF-alpha induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle.
Title: Cyclic Tensile Strain Reduces TNF-α Induced Expression of MMP-13 by Condylar Temporomandibular Joint Cells.
TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.
Title: Effects of interleukin 6 and tumor necrosis factor-α on the proliferation of porcine theca interna cells: Possible role of these cytokines in the pathogenesis of polycystic ovary syndrome.
This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 resistance.
Title: Effects of the -791(C→T) mutation in the promoter for tumor necrosis factor alpha on gene expression and resistance of Large White pigs to enterotoxigenic Escherichia coli F18.

Submit: New GeneRIF Correction See all GeneRIFs (36)

General gene information

Go to the top of the page Help

Markers

Tnf (e-PCR), detects polymorphism
- UniSTS:144649

GDB:624603 (e-PCR)
- UniSTS:158353

GDB:624619 (e-PCR)
- UniSTS:158354

TNFA-2 (e-PCR)
- UniSTS:253858

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables CD40 receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: tumor necrosis factor

Names: TNF-a; TNF-alpha; cachectin; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.