VEGFA vascular endothelial growth factor A [Sus scrofa (pig)] - Gene

Summary

Official Symbol: VEGFAprovided by VGNC
Official Full Name: vascular endothelial growth factor Aprovided by VGNC
Primary source: VGNC:VGNC:94815
See related: Ensembl:ENSSSCG00000001695
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: VEGF
Annotation information: Annotation category: partial on reference assembly
Expression: Ubiquitous expression in psoas major muscle (RPKM 66.2), kidney (RPKM 58.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	7	NC_010449.5 (38746393..38762282)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	7	NC_010449.4 (44459821..44475711)

Chromosome 7 - NC_010449.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Influence of Melatonin and Light on VEGF Secretion in Primary RPE Cells.
Title: The Influence of Melatonin and Light on VEGF Secretion in Primary RPE Cells.
Epidural Stimulation Combined with Triple Gene Therapy for Spinal Cord Injury Treatment.
Title: Epidural Stimulation Combined with Triple Gene Therapy for Spinal Cord Injury Treatment.
Inhibition of ssc-microRNA-140-5p ameliorates the Clostridium perfringens beta2 toxin-induced inflammatory response in IPEC-J2 cells via the ERK1/2 and JNK pathways by targeting VEGFA.
Title: Inhibition of ssc-microRNA-140-5p ameliorates the Clostridium perfringens beta2 toxin-induced inflammatory response in IPEC-J2 cells via the ERK1/2 and JNK pathways by targeting VEGFA.
MMP9 and VEGF, but not MMP13 or FGF23 may have roles in bone lesions in the hypovitaminosis D kyphotic pig model
Title: Gene expression of matrix metalloproteinase 9 (MMP9), matrix metalloproteinase 13 (MMP13), vascular endothelial growth factor (VEGF) and fibroblast growth factor 23 (FGF23) in femur and vertebra tissues of the hypovitaminosis D kyphotic pig model.
It regulates endometrial remodeling in the porcine endometrial tissues during follicular and luteal phase.
Title: The expression of VEGF, myoglobin and CRP2 proteins regulating endometrial remodeling in the porcine endometrial tissues during follicular and luteal phase.
It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.
Title: Expression of vascular endothelial growth factor (VEGF) and factor VIII in the gilt placenta and its relation to fetal development.
results are consistent with a participation of (VEFG) in the regulation of the dynamics of oviductal fluid secretion and the oviduct contractibility
Title: Expression of the vascular endothelial growth factor system (VEGF) in the porcine oviduct during the estrous cycle.
Here we demonstrate that VEGF-165 mediates MSC differentiation into ECs via VEGFR-2-dependent induction of Sox18, which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.
Title: Sry-type HMG box 18 contributes to the differentiation of bone marrow-derived mesenchymal stem cells to endothelial cells.
VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.
Title: [Effect of cryotherapy over the expression of vascular endothelial growth factor and pigment epithelium-derived factor].
VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.
Title: Effect of antiprogesterone RU486 on VEGF expression and blood vessel remodeling on ovarian follicles before ovulation.

Submit: New GeneRIF Correction See all GeneRIFs (31)

General gene information

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Markers

Vegfa (e-PCR), detects polymorphism
- UniSTS:471318

Vegfa (e-PCR), detects polymorphism
- UniSTS:462632

VEGF (e-PCR), detects polymorphism
- UniSTS:505661

Vegf (e-PCR), detects polymorphism
- UniSTS:144751

Vegf (e-PCR), detects polymorphism
- UniSTS:144752

GDB:580706 (e-PCR)
- UniSTS:157849

PMC25276P1 (e-PCR)
- UniSTS:272284

NoName (e-PCR)
- UniSTS:251317

MARC_5691-5692:991939678:1 (e-PCR)
- UniSTS:231163

MARC_5693-5694:991939688:1 (e-PCR)
- UniSTS:231164

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables chemoattractant activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables heparin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables vascular endothelial growth factor receptor 1 binding	IEA Inferred from Electronic Annotation more info	PubMed
enables vascular endothelial growth factor receptor 2 binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in induction of positive chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of mast cell chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: vascular endothelial growth factor A

Names: VEGF-A; VPF; vascular permeability factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214084.1 → NP_999249.1 vascular endothelial growth factor A precursor

See identical proteins and their annotated locations for NP_999249.1

Status: PROVISIONAL

Source sequence(s)

AF318502

UniProtKB/TrEMBL

A0A068J2Q8

Conserved Domains (2) summary

smart00141
Location:49 → 131

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:139 → 190

VEGF_C; VEGF heparin-binding domain

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010449.5 Reference Sscrofa11.1 Primary Assembly

Range

38746393..38762282

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_013977975.1 → XP_013833429.1 vascular endothelial growth factor A isoform X1

UniProtKB/TrEMBL

A0A4X1V7P2, A0A8D1UYA2

Related

ENSSSCP00000072498.2, ENSSSCT00000073564.2

Conserved Domains (1) summary

smart00141
Location:286 → 368

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family