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CCK cholecystokinin [ Sus scrofa (pig) ]

Gene ID: 397468, updated on 17-Aug-2024

Summary

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Official Symbol
CCKprovided by VGNC
Official Full Name
cholecystokininprovided by VGNC
Primary source
VGNC:VGNC:86334
See related
Ensembl:ENSSSCG00000011277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Restricted expression toward heart (RPKM 472.9) See more
Orthologs
human mouse all
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Genomic context

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See CCK in Genome Data Viewer
Location:
chromosome: 13
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (25940674..25945879, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (28610211..28615371, complement)

Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene trafficking kinesin protein 1 Neighboring gene uncharacterized LOC110256272 Neighboring gene lysozyme like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Synthesis of cholecystokinin-pancreozymin. I. The C-terminal dodecapeptide. Ondetti MA, et al. J Am Chem Soc, 1970 Jan 14. PMID 5410106
  2. Cloned cDNA to cholecystokinin mRNA predicts an identical preprocholecystokinin in pig brain and gut. Gubler U, et al. Proc Natl Acad Sci U S A, 1984 Jul. PMID 6205394, Free PMC Article
  3. Analysis of sequence requirements for protein tyrosine sulfation. Rosenquist GL, et al. Protein Sci, 1993 Feb. PMID 8443599, Free PMC Article
  4. Polymerase chain reaction-based polymorphisms in the porcine cholecystokinin (CCK) gene and assignment to chromosome 13. Clutter AC, et al. Anim Genet, 1996 Oct. PMID 8930082
  5. Nonsulfated cholecystokinins in cerebral neurons. Agersnap M, et al. Neuropeptides, 2016 Dec. PMID 27535680

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Haemodynamic changes seem to regulate regional proCCK expression in the mammalian heart.
    Title: Cardiac procholecystokinin expression during haemodynamic changes in the mammalian heart.
  2. We conclude that only a small fraction of neuronal CCK is nonsulfated. The intracellular distribution of nonsulfated CCK in neurons suggests that they contribute only modestly to the CCK transmitter activity.
    Title: Nonsulfated cholecystokinins in cerebral neurons.
  3. Cardiac expression of pro-cholecystokinin is cell-specific, which differentiates the expression from that of intestinal endocrine cells and cerebral neurons.
    Title: Cardiomyocyte expression and cell-specific processing of procholecystokinin.
  4. This review explores the role of luminal cholecystokinin on the regulation of exocrine pancreatic secretion in author's studies of neonatal pigs.
    Title: Luminal CCK and its neuronal action on exocrine pancreatic secretion.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables neuropeptide hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in digestion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cholecystokinin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214237.2 → NP_999402.1  cholecystokinin precursor

    See identical proteins and their annotated locations for NP_999402.1

    Status: VALIDATED

    Source sequence(s)
    AEMK02000085, EW238422
    UniProtKB/Swiss-Prot
    P01356
    UniProtKB/TrEMBL
    A0A4X1TLX5
    Related
    ENSSSCP00000012023.4, ENSSSCT00000012346.5
    Conserved Domains (1) summary
    pfam00918
    Location:4 → 114
    Gastrin; Gastrin/cholecystokinin family

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

    Range
    25940674..25945879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021068544.1 → XP_020924203.1  cholecystokinin isoform X2

    UniProtKB/TrEMBL
    A0A2C9F3A0, A0A8D0UFZ8, A0A8D1A2Z0
    Conserved Domains (1) summary
    pfam00918
    Location:44 → 154
    Gastrin; Gastrin/cholecystokinin family

  2. XM_005669402.3 → XP_005669459.3  cholecystokinin isoform X1

    UniProtKB/TrEMBL
    A0A8D1A2Z0
    Conserved Domains (1) summary
    pfam00918
    Location:44 → 164
    Gastrin; Gastrin/cholecystokinin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01356.1 GenPept UniProtKB/Swiss-Prot:P01356

Gene LinkOut

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