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VDAC2 voltage dependent anion channel 2 [ Sus scrofa (pig) ]

Gene ID: 397659, updated on 17-Aug-2024

Summary

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Official Symbol
VDAC2provided by VGNC
Official Full Name
voltage dependent anion channel 2provided by VGNC
Primary source
VGNC:VGNC:111154
See related
Ensembl:ENSSSCG00000010320
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in heart (RPKM 284.8), psoas major muscle (RPKM 202.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See VDAC2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (77767165..77782327)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003613220.1 (10525..22960)

Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 13B Neighboring gene sterile alpha motif domain containing 8 Neighboring gene uncharacterized LOC106507128 Neighboring gene catechol-O-methyltransferase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Deubiquitinase UCHL1 regulates estradiol synthesis by stabilizing voltage-dependent anion channel 2. Shi S, et al. J Biol Chem, 2023 Nov. PMID 37797697, Free PMC Article
  2. MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals. Yuan J, et al. Autophagy, 2015. PMID 26060891, Free PMC Article
  3. Voltage-dependent anion channels 1 and 2 are expressed in porcine oocytes. Cassará MC, et al. Biosci Rep, 2009 Dec 15. PMID 19630752
  4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deubiquitinase UCHL1 regulates estradiol synthesis by stabilizing voltage-dependent anion channel 2.
    Title: Deubiquitinase UCHL1 regulates estradiol synthesis by stabilizing voltage-dependent anion channel 2.
  2. an important MYBL2-VDAC2-BECN1-BCL2L1 pathway linking autophagy suppression in the developing ovary, is reported.
    Title: MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals.
  3. Data confirm the synthesis of VDAC1 and 2 subtypes in GV (germinal vesicle) and MII (meiosis II) stage porcine oocytes as well as their protein expression.
    Title: Voltage-dependent anion channels 1 and 2 are expressed in porcine oocytes.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables voltage-gated monoatomic anion channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
voltage-dependent anion-selective channel protein 2
Names
VDAC-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214369.1 → NP_999534.1  voltage-dependent anion-selective channel protein 2

    See identical proteins and their annotated locations for NP_999534.1

    Status: PROVISIONAL

    Source sequence(s)
    AF268462
    UniProtKB/TrEMBL
    A0A8D1S295
    Conserved Domains (1) summary
    cd07306
    Location:15 → 293
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

    Range
    77767165..77782327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021072175.1 → XP_020927834.1  voltage-dependent anion-selective channel protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A0A4X1SP14, F1S2F6, Q9MZ15
    UniProtKB/TrEMBL
    A0A8D0JI73, A0A8D1S295
    Related
    ENSSSCP00000011005.3, ENSSSCT00000011297.5
    Conserved Domains (1) summary
    cd07306
    Location:15 → 293
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MZ15.2 GenPept UniProtKB/Swiss-Prot:Q9MZ15

Gene LinkOut

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