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ARHGDIG Rho GDP dissociation inhibitor gamma [ Homo sapiens (human) ]

Gene ID: 398, updated on 2-Nov-2024

Summary

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Official Symbol
ARHGDIGprovided by HGNC
Official Full Name
Rho GDP dissociation inhibitor gammaprovided by HGNC
Primary source
HGNC:HGNC:680
See related
Ensembl:ENSG00000242173 MIM:602844; AllianceGenome:HGNC:680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RHOGDI-3
Summary
The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
Expression
Biased expression in brain (RPKM 34.7), duodenum (RPKM 7.8) and 4 other tissues See more
Orthologs
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Genomic context

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See ARHGDIG in Genome Data Viewer
Location:
16p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (280591..283010)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (275429..277879)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (330591..333010)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:284237-284780 Neighboring gene C4orf46 pseudogene 1 Neighboring gene family with sequence similarity 234 member A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:307431-308390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:322947-323484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:323485-324021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:325209-325860 Neighboring gene regulator of G protein signaling 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:330732-331489 Neighboring gene protein disulfide isomerase family A member 2 Neighboring gene axin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:359414-359928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:359929-360443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:366745-367498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:367499-368250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:368251-369004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:374949-375556 Neighboring gene Sharpr-MPRA regulatory region 4309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:389458-390182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:391465-392016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6911

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3. Adra CN, et al. Genomics, 1998 Oct 1. PMID 9787082
  2. RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain. Brunet N, et al. Traffic, 2002 May. PMID 11967128
  3. Immunological and Functional Characterization of RhoGDI3 and Its Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and Normal Cells. de León-Bautista MP, et al. PLoS One, 2016. PMID 27832197, Free PMC Article
  4. Integrins regulate Rac targeting by internalization of membrane domains. del Pozo MA, et al. Science, 2004 Feb 6. PMID 14764880
  5. RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. Adra CN, et al. Proc Natl Acad Sci U S A, 1997 Apr 29. PMID 9113980, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RhoGDI3 at the trans-Golgi network participates in NLRP3 inflammasome activation, VSMC phenotypic modulation, and neointima formation.
    Title: RhoGDI3 at the trans-Golgi network participates in NLRP3 inflammasome activation, VSMC phenotypic modulation, and neointima formation.
  2. These results suggest that the levels of RhoG and RhoB GTPases and their negative regulator RhoGDI3 might be linked to the aggressiveness of the pancreatic cancerous cell lines. It is possible that RhoGDI3 could induce the downregulation of RhoG and RhoB.
    Title: Immunological and Functional Characterization of RhoGDI3 and Its Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and Normal Cells.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.
  4. analysis of inhibitory and shuttling functions of rhoGDI-3 and rhoGDI-1
    Title: Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: PDIA2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in blastocyst hatching IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of protein localization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
rho GDP-dissociation inhibitor 3
Names
Rho GDP dissociation inhibitor (GDI) gamma
RhoGDI gamma
rho GDI 3
rho-GDI gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001176.4 → NP_001167.2  rho GDP-dissociation inhibitor 3

    See identical proteins and their annotated locations for NP_001167.2

    Status: VALIDATED

    Source sequence(s)
    BC047699, BM662457, Z69667
    Consensus CDS
    CCDS10404.1
    UniProtKB/Swiss-Prot
    Q4TT69, Q96S29, Q99819
    UniProtKB/TrEMBL
    F1T0H7, Q4TT68
    Related
    ENSP00000219409.3, ENST00000219409.8
    Conserved Domains (1) summary
    pfam02115
    Location:42 → 222
    Rho_GDI; RHO protein GDP dissociation inhibitor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    280591..283010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    275429..277879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99819.2 GenPept UniProtKB/Swiss-Prot:Q99819

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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