ltbp1.S latent transforming growth factor beta binding protein 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ltbp1.S
Official Full Name: latent transforming growth factor beta binding protein 1 S homeolog
Primary source: Xenbase:XB-GENE-865760
Locus tag: XELAEV_18028979mg
See related: EnsemblRapid:ENSXLAG00005005761 AllianceGenome:Xenbase:XB-GENE-865760
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ltbp1; ltgf-1; TGFbBP1
Summary: Predicted to enable calcium ion binding activity. Is expressed in cardiovascular system; musculoskeletal system; nervous system; and primary germ layer. Human ortholog(s) of this gene implicated in cutis laxa. Orthologous to human LTBP1 (latent transforming growth factor beta binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 5S

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (38029495..38146537)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (37903728..38020803)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: latent transforming growth factor beta binding protein 1 S homeolog

Names: latent TGF-beta binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088785.1 → NP_001082254.1 latent transforming growth factor beta binding protein 1 S homeolog precursor

See identical proteins and their annotated locations for NP_001082254.1

Status: PROVISIONAL

Source sequence(s)

AJ421626

UniProtKB/TrEMBL

Q8AXM6, Q8JFZ4

Related

ENSXLAP00005017157.1, ENSXLAT00005017453.1

Conserved Domains (5) summary

smart00179
Location:826 → 867

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:702 → 733

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00683
Location:361 → 396

TB; TB domain

pfam12662
Location:724 → 747

cEGF; Complement Clr-like EGF-like

cl00057
Location:572 → 613

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...