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LIMS1 LIM zinc finger domain containing 1 [ Homo sapiens (human) ]

Gene ID: 3987, updated on 3-Nov-2024

Summary

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Official Symbol
LIMS1provided by HGNC
Official Full Name
LIM zinc finger domain containing 1provided by HGNC
Primary source
HGNC:HGNC:6616
See related
Ensembl:ENSG00000169756 MIM:602567; AllianceGenome:HGNC:6616
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PINCH; PINCH1; PINCH-1
Summary
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in endometrium (RPKM 18.5), adrenal (RPKM 16.0) and 25 other tissues See more
Orthologs
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Genomic context

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See LIMS1 in Genome Data Viewer
Location:
2q12.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (108533671..108687246)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (108994291..109147842)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (109150127..109303702)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 12 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:109064602-109065584 and GRCh37_chr2:109065585-109066566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109066652-109067152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109067153-109067653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16343 Neighboring gene GRIP and coiled-coil domain containing 2 Neighboring gene 2q12.3 distal recombination region Neighboring gene GCC2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16344 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:109191556-109192512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16345 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:109210352-109211551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16348 Neighboring gene NANOG hESC enhancer GRCh37_chr2:109225689-109226190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16349 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109252737-109253311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:109271409-109272023 Neighboring gene Sharpr-MPRA regulatory region 6630 Neighboring gene LIMS1 antisense RNA 1 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial-like Neighboring gene ribosomal protein L10 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prognostic significance of PINCH signalling in human pancreatic ductal adenocarcinoma. Scaife CL, et al. HPB (Oxford), 2010 Jun. PMID 20590912, Free PMC Article
  2. High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis. Tsinias G, et al. Anal Cell Pathol (Amst), 2018. PMID 29755929, Free PMC Article
  3. Knockdown of PINCH-1 protein sensitizes the estrogen positive breast cancer cells to chemotherapy induced apoptosis. Bhatia A, et al. Pathol Res Pract, 2018 Feb. PMID 29079319
  4. Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection. Steers NJ, et al. N Engl J Med, 2019 May 16. PMID 31091373, Free PMC Article
  5. Changes in PINCH levels in the CSF of HIV+ individuals correlate with hpTau and CD4 count. Adiga R, et al. J Neurovirol, 2014 Aug. PMID 24817145, Free PMC Article

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RNA-binding protein RBMS3 inhibits the progression of colon cancer by regulating the stability of LIMS1 mRNA.
    Title: The RNA-binding protein RBMS3 inhibits the progression of colon cancer by regulating the stability of LIMS1 mRNA.
  2. Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
    Title: Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
  3. A mechanoresponsive PINCH-1-Notch2 interaction regulates smooth muscle differentiation of human placental mesenchymal stem cells.
    Title: A mechanoresponsive PINCH-1-Notch2 interaction regulates smooth muscle differentiation of human placental mesenchymal stem cells.
  4. Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly.
    Title: Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly.
  5. Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons.
    Title: Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons.
  6. MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.
    Title: MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.
  7. PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis.
    Title: PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis.
  8. PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
    Title: PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
  9. The PINCH-1 interacts with Smurf1, which inhibits the latter from interacting with BMPR2 and consequently suppresses BMPR2 degradation, resulting in augmented BMP signaling and MSC osteogenic differentiation (OD).
    Title: A PINCH-1-Smurf1 signaling axis mediates mechano-regulation of BMPR2 and stem cell differentiation.
  10. We found that the LIMS1 locus appeared to encode a minor histocompatibility antigen. Genomic collision at this locus was associated with rejection of the kidney allograft and with production of anti-LIMS1 IgG2 and IgG3.
    Title: Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
NOT involved_in epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
LIM and senescent cell antigen-like-containing domain protein 1
Names
LIM and senescent cell antigen-like domains 1
LIM-type zinc finger domains 1
particularly interesting new Cys-His protein 1
renal carcinoma antigen NY-REN-48
senescent cell antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193482.2 → NP_001180411.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC010095, AC012487, AF527762, AL110164
    Consensus CDS
    CCDS54383.1
    UniProtKB/Swiss-Prot
    P48059
    Related
    ENSP00000386926.1, ENST00000410093.5
    Conserved Domains (5) summary
    cd09331
    Location:14 → 72
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:75 → 126
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:139 → 189
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:195 → 248
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:256 → 309
    LIM5_PINCH; The fifth LIM domain of protein PINCH

  2. NM_001193483.3 → NP_001180412.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform d

    See identical proteins and their annotated locations for NP_001180412.1

    Status: REVIEWED

    Source sequence(s)
    AC010095, AC012487
    Consensus CDS
    CCDS54382.1
    UniProtKB/Swiss-Prot
    P48059
    Related
    ENSP00000437912.1, ENST00000544547.6
    Conserved Domains (5) summary
    cd09331
    Location:22 → 80
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:83 → 134
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:147 → 197
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:203 → 256
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:264 → 317
    LIM5_PINCH; The fifth LIM domain of protein PINCH

  3. NM_001193484.2 → NP_001180413.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform e

    See identical proteins and their annotated locations for NP_001180413.1

    Status: REVIEWED

    Source sequence(s)
    AC010095, AF527761, AK304260, AL110164
    Consensus CDS
    CCDS54384.1
    UniProtKB/Swiss-Prot
    P48059
    Related
    ENSP00000387264.1, ENST00000409441.5
    Conserved Domains (5) summary
    cd09331
    Location:47 → 105
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:108 → 159
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:172 → 222
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:228 → 281
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:289 → 342
    LIM5_PINCH; The fifth LIM domain of protein PINCH

  4. NM_001193485.3 → NP_001180414.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform a

    See identical proteins and their annotated locations for NP_001180414.1

    Status: REVIEWED

    Source sequence(s)
    AC010095, AF527759, AL110164
    Consensus CDS
    CCDS54385.1
    UniProtKB/Swiss-Prot
    P48059
    Related
    ENSP00000337598.4, ENST00000338045.7
    Conserved Domains (5) summary
    cd09331
    Location:72 → 130
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:133 → 184
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:197 → 247
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:253 → 306
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:314 → 367
    LIM5_PINCH; The fifth LIM domain of protein PINCH

  5. NM_001193488.2 → NP_001180417.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform b

    See identical proteins and their annotated locations for NP_001180417.1

    Status: REVIEWED

    Source sequence(s)
    AC010095, AC012487, AF527763, AL110164, BC005341
    Consensus CDS
    CCDS2078.1
    UniProtKB/Swiss-Prot
    B2RAJ4, B7Z483, B7Z7R3, B7Z907, P48059, Q53TE0, Q9BS44
    Related
    ENSP00000376987.1, ENST00000393310.5
    Conserved Domains (5) summary
    cd09331
    Location:10 → 68
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:71 → 122
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:135 → 185
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:191 → 244
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:252 → 305
    LIM5_PINCH; The fifth LIM domain of protein PINCH

  6. NM_001371494.1 → NP_001358423.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC010095
    Consensus CDS
    CCDS92833.1
    UniProtKB/TrEMBL
    A0A8Q3WKK6
    Related
    ENSP00000511985.1, ENST00000695522.1
    Conserved Domains (5) summary
    cd09331
    Location:72 → 130
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:133 → 184
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:197 → 247
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:253 → 306
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:314 → 367
    LIM5_PINCH; The fifth LIM domain of protein PINCH

  7. NM_001371495.1 → NP_001358424.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC010095, AC012487
    Consensus CDS
    CCDS92830.1
    UniProtKB/TrEMBL
    A0A8Q3WKP0
    Related
    ENSP00000511980.1, ENST00000695517.1
    Conserved Domains (5) summary
    cd09331
    Location:22 → 80
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:83 → 134
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:147 → 197
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:203 → 256
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:264 → 317
    LIM5_PINCH; The fifth LIM domain of protein PINCH

  8. NM_001371496.1 → NP_001358425.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC010095, AC012487
    Consensus CDS
    CCDS92829.1
    UniProtKB/TrEMBL
    A0A8Q3WKI3
    Related
    ENSP00000511979.1, ENST00000695516.1
    Conserved Domains (5) summary
    cd09331
    Location:31 → 89
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:92 → 143
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:156 → 206
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:212 → 265
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:273 → 326
    LIM5_PINCH; The fifth LIM domain of protein PINCH

  9. NM_001371497.1 → NP_001358426.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC010095, AC012487
    Consensus CDS
    CCDS92831.1
    UniProtKB/TrEMBL
    A0A8Q3WKJ2
    Related
    ENSP00000511982.1, ENST00000695519.1
    Conserved Domains (5) summary
    cd09331
    Location:17 → 75
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:78 → 129
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:142 → 192
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:198 → 251
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:259 → 312
    LIM5_PINCH; The fifth LIM domain of protein PINCH

  10. NM_001371498.1 → NP_001358427.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC010095, AC012487
    Consensus CDS
    CCDS2078.1
    UniProtKB/Swiss-Prot
    B2RAJ4, B7Z483, B7Z7R3, B7Z907, P48059, Q53TE0, Q9BS44
    Related
    ENSP00000511981.1, ENST00000695518.1
    Conserved Domains (5) summary
    cd09331
    Location:10 → 68
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:71 → 122
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:135 → 185
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:191 → 244
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:252 → 305
    LIM5_PINCH; The fifth LIM domain of protein PINCH

  11. NM_001371499.1 → NP_001358428.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC010095
    Consensus CDS
    CCDS92832.1
    UniProtKB/TrEMBL
    B2R5G4, F8WC86
    Related
    ENSP00000399267.2, ENST00000414829.2
    Conserved Domains (1) summary
    cd09331
    Location:72 → 114
    LIM1_PINCH; The first LIM domain of protein PINCH

  12. NM_001371500.1 → NP_001358429.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC010095
    UniProtKB/TrEMBL
    F8WE10
    Conserved Domains (1) summary
    cd09331
    Location:47 → 89
    LIM1_PINCH; The first LIM domain of protein PINCH

  13. NM_001394896.1 → NP_001381825.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC010095, AC012487
    Conserved Domains (5) summary
    cd09331
    Location:22 → 80
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:83 → 134
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:147 → 197
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:203 → 256
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:264 → 317
    LIM5_PINCH; The fifth LIM domain of protein PINCH

  14. NM_001394897.1 → NP_001381826.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform m

    Status: REVIEWED

    Source sequence(s)
    AC010095, AC012487
    Conserved Domains (5) summary
    cd09331
    Location:10 → 68
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:71 → 122
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:135 → 185
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:191 → 244
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:252 → 305
    LIM5_PINCH; The fifth LIM domain of protein PINCH

  15. NM_001394898.1 → NP_001381827.1  LIM and senescent cell antigen-like-containing domain protein 1 isoform n

    Status: REVIEWED

    Source sequence(s)
    AC010095, AC012487
    Conserved Domains (1) summary
    cd09331
    Location:31 → 73
    LIM1_PINCH; The first LIM domain of protein PINCH

  16. NM_004987.6 → NP_004978.2  LIM and senescent cell antigen-like-containing domain protein 1 isoform b

    See identical proteins and their annotated locations for NP_004978.2

    Status: REVIEWED

    Source sequence(s)
    AC010095, AL110164, BG942518, U09284
    Consensus CDS
    CCDS2078.1
    UniProtKB/Swiss-Prot
    B2RAJ4, B7Z483, B7Z7R3, B7Z907, P48059, Q53TE0, Q9BS44
    Related
    ENSP00000331775.6, ENST00000332345.10
    Conserved Domains (5) summary
    cd09331
    Location:10 → 68
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:71 → 122
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:135 → 185
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:191 → 244
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:252 → 305
    LIM5_PINCH; The fifth LIM domain of protein PINCH

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    108533671..108687246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    108994291..109147842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48059.4 GenPept UniProtKB/Swiss-Prot:P48059

Gene LinkOut

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