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SLC25A35 solute carrier family 25 member 35 [ Homo sapiens (human) ]

Gene ID: 399512, updated on 5-Mar-2024

Summary

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Official Symbol
SLC25A35provided by HGNC
Official Full Name
solute carrier family 25 member 35provided by HGNC
Primary source
HGNC:HGNC:31921
See related
Ensembl:ENSG00000125434 MIM:610818; AllianceGenome:HGNC:31921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
SLC25A35 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 9.0), endometrium (RPKM 4.9) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
17p13.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8287763..8295400, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8194005..8201639, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8191081..8198718, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tRNA-Ile (anticodon AAT) 4-1 Neighboring gene CST telomere replication complex component 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11691 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8152035-8152791 Neighboring gene phosphoribosylformylglycinamidine synthase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8187618-8188118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8188119-8188619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11695 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11697 Neighboring gene RAN guanine nucleotide release factor Neighboring gene uncharacterized LOC124903915 Neighboring gene uncharacterized LOC124903914 Neighboring gene CRISPRi-validated cis-regulatory element chr17.641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8213553-8214053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8216427-8216928 Neighboring gene Rho guanine nucleotide exchange factor 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. Haitina T, et al. Genomics, 2006 Dec. PMID 16949250
  2. The mitochondrial transporter family SLC25: identification, properties and physiopathology. Palmieri F. Mol Aspects Med, 2013 Apr-Jun. PMID 23266187
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. Hendrickson SL, et al. PLoS One, 2010 Sep 21. PMID 20877624, Free PMC Article
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. Giurato G, et al. Sci Data, 2018 Mar 6. PMID 29509190, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Compares and contrasts all the known human SLC25A* genes and includes functional information.
    Title: The mitochondrial transporter family SLC25: identification, properties and physiopathology.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ40217, MGC120446, MGC120448

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 25 member 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320870.2 → NP_001307799.1  solute carrier family 25 member 35 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC135178, BC041597, BC105995, BM987725
    Consensus CDS
    CCDS82067.1
    UniProtKB/Swiss-Prot
    Q3KQZ1, Q494X5, Q6RGS3, Q8N7Y5
    Related
    ENSP00000464231.1, ENST00000577745.2
    Conserved Domains (1) summary
    pfam00153
    Location:209 → 298
    Mito_carr; Mitochondrial carrier protein

  2. NM_001320871.2 → NP_001307800.1  solute carrier family 25 member 35 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' structure compared to variant 1. The encoded isoform (b) has a distinct C-terminus, and is shorter than isofom a. Variants 2 through 4 encodes the same isoform.
    Source sequence(s)
    AC135178, BC052233
    Consensus CDS
    CCDS11138.1
    UniProtKB/Swiss-Prot
    Q3KQZ1
    Related
    ENSP00000462395.1, ENST00000579192.5
    Conserved Domains (2) summary
    pfam00153
    Location:2 → 84
    Mito_carr; Mitochondrial carrier protein
    cl28162
    Location:119 → 194
    Mito_carr; Mitochondrial carrier protein

  3. NM_001320872.2 → NP_001307801.1  solute carrier family 25 member 35 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' structure compared to variant 1. The encoded isoform (b) has a distinct C-terminus, and is shorter than isofom a. Variants 2 through 4 encodes the same isoform.
    Source sequence(s)
    AC135178, BC052233, BC101329, BC101330
    Consensus CDS
    CCDS11138.1
    UniProtKB/Swiss-Prot
    Q3KQZ1
    Related
    ENSP00000464071.1, ENST00000580340.5
    Conserved Domains (2) summary
    pfam00153
    Location:2 → 84
    Mito_carr; Mitochondrial carrier protein
    cl28162
    Location:119 → 194
    Mito_carr; Mitochondrial carrier protein

  4. NM_001320877.2 → NP_001307806.1  solute carrier family 25 member 35 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a
    Source sequence(s)
    AC135178
    Conserved Domains (1) summary
    pfam00153
    Location:187 → 276
    Mito_carr; Mitochondrial carrier protein

  5. NM_201520.3 → NP_958928.1  solute carrier family 25 member 35 isoform b

    See identical proteins and their annotated locations for NP_958928.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' structure compared to variant 1. The encoded isoform (b) has a distinct C-terminus, and is shorter than isofom a. Variants 2 through 4 encodes the same isoform.
    Source sequence(s)
    AC135178, AK097536, BC041597
    Consensus CDS
    CCDS11138.1
    UniProtKB/Swiss-Prot
    Q3KQZ1
    Related
    ENSP00000369407.2, ENST00000380067.6
    Conserved Domains (2) summary
    pfam00153
    Location:2 → 84
    Mito_carr; Mitochondrial carrier protein
    cl28162
    Location:119 → 194
    Mito_carr; Mitochondrial carrier protein

RNA

  1. NR_135483.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC135178, AY498866, BC052233, BC101330

  2. NR_135484.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC135178, BC052233, BC101330

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    8287763..8295400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436000.1 → XP_047291956.1  solute carrier family 25 member 35 isoform X2

    Related
    ENSP00000464307.1, ENST00000579681.5

  2. XM_047435999.1 → XP_047291955.1  solute carrier family 25 member 35 isoform X1

    Related
    ENSP00000464191.1, ENST00000585311.5

  3. XM_005256641.4 → XP_005256698.1  solute carrier family 25 member 35 isoform X3

    Conserved Domains (1) summary
    pfam00153
    Location:2 → 84
    Mito_carr; Mitochondrial carrier protein

  4. XM_047436001.1 → XP_047291957.1  solute carrier family 25 member 35 isoform X4

RNA

  1. XR_007065297.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    8194005..8201639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316089.1 → XP_054172064.1  solute carrier family 25 member 35 isoform X2

  2. XM_054316088.1 → XP_054172063.1  solute carrier family 25 member 35 isoform X1

  3. XM_054316090.1 → XP_054172065.1  solute carrier family 25 member 35 isoform X3

  4. XM_054316091.1 → XP_054172066.1  solute carrier family 25 member 35 isoform X4

RNA

  1. XR_008484818.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KQZ1.1 GenPept UniProtKB/Swiss-Prot:Q3KQZ1

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