FABP3 fatty acid binding protein 3 [Sus scrofa (pig)] - Gene

Summary

Gene symbol: FABP3
Gene description: fatty acid binding protein 3
See related: Ensembl:ENSSSCG00000036883
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: H-FABP
Expression: Broad expression in psoas major muscle (RPKM 1195.9), heart (RPKM 1092.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (87943003..87950708, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	6	NC_010448.3 (81714138..81715645)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of H-FABP at both mRNA and protein levels in the tissues of backfat, longissimus dorsi muscle and liver was found to be significantly higher in Tibetan pig than in Large White pig; study provides important data for further investigating the regulatory mechanism of H-FABP for fat deposition in pigs.
Title: Expression and single-nucleotide polymorphisms of the H-FABP gene in pigs.
SNPs in the FABP3 promoter may contribute to intramuscular fat without influencing carcass fatness traits in pigs
Title: Novel variation in the FABP3 promoter and its association with fatness traits in pigs.
Expression of the FABP3 gene enhances adipogenesis in 3T3-L1 preadipocytes primarily by upregulating lipogenic genes.
Title: Overexpression of Banna mini-pig inbred line fatty acid binding protein 3 promotes adipogenesis in 3T3-L1 preadipocytes.
Results indicate that fatty acid binding protein H-FABP and CoA ligase 4 ACSL4 genes might serve as markers to improve fat (IMF) content in the breeding system.
Title: Distribution of H-FABP and ACSL4 gene polymorphisms and their associations with intramuscular fat content and backfat thickness in different pig populations.
hFABP rises faster and correlates better with infarct size and no-reflow than hsTnI in myocardial infarction + reperfusion when measured early after reperfusion.
Title: Serial measurement of hFABP and high-sensitivity troponin I post-PCI in STEMI: how fast and accurate can myocardial infarct size and no-reflow be predicted?
Linkage disequilibrium analysis among MC4R, LEP and H-FABP revealed that these genes were independent.
Title: Distribution and linkage disequilibrium analysis of polymorphisms of MC4R, LEP, H-FABP genes in the different populations of pigs, associated with economic traits in DIV2 line.
The FABP3 polymorphisms can be used as genetic markers in breeding programs for intramuscular fat content as well as carcass back fat thickness.
Title: Association of genetic variants for FABP3 gene with back fat thickness and intramuscular fat content in pig.
The H-FABP MspI RFLP genotype affected unsaturated fatty acid content, and the ratio of polyunsaturated fatty acid to saturated fatty acid (P<0.05), whereas the H-FABP HaeIII RFLP genotype had no effect on fatty acid characteristics.
Title: Association between polymorphisms of the heart fatty acid binding protein gene and intramuscular fat content, fatty acid composition, and meat quality in Berkshire breed.
The objective of this study was to investigate the effect of FABP3 and LEPR genetic variations as well as their mRNA expression on the intramuscular fat content trait in a three-generation of Korean native pig and Yorkshire crossed animals.
Title: Investigation of porcine FABP3 and LEPR gene polymorphisms and mRNA expression for variation in intramuscular fat content.
Sirt1 regulates the expression of FABP3 gene in adipocytes, and PPAR gamma apparently plays an important role in this process.
Title: Regulatory role of Sirt1 on the gene expression of fatty acid-binding protein 3 in cultured porcine adipocytes.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

HFABPMS (e-PCR)
- UniSTS:253495

HFABP (e-PCR), detects polymorphism
- UniSTS:498618

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables fatty acid binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fatty acid-binding protein, heart

Names: fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.