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FAM177B family with sequence similarity 177 member B [ Homo sapiens (human) ]

Gene ID: 400823, updated on 17-Sep-2024

Summary

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Official Symbol
FAM177Bprovided by HGNC
Official Full Name
family with sequence similarity 177 member Bprovided by HGNC
Primary source
HGNC:HGNC:34395
See related
Ensembl:ENSG00000197520 AllianceGenome:HGNC:34395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in stomach (RPKM 8.5), colon (RPKM 2.2) and 6 other tissues See more
Orthologs
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Genomic context

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See FAM177B in Genome Data Viewer
Location:
1q41
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (222737202..222751004)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (221970958..221984766)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (222910544..222924346)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5183 Neighboring gene axin interactor, dorsalization associated Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:222885601-222886515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5205 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:222909786-222910327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1836 Neighboring gene BRO1 domain and CAAX motif containing Neighboring gene uncharacterized LOC105372984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1837 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1839 Neighboring gene dispatched RND transporter family member 1 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Need AC, et al. Hum Mol Genet, 2009 Dec 1. PMID 19734545, Free PMC Article
  2. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Wu SF, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513696, Free PMC Article
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ43505

General protein information

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Preferred Names
protein FAM177B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324080.2 → NP_001311009.1  protein FAM177B

    Status: VALIDATED

    Source sequence(s)
    AL392172
    Consensus CDS
    CCDS1535.2
    UniProtKB/Swiss-Prot
    A6PVY3, Q6ZUN8
    Conserved Domains (1) summary
    pfam14774
    Location:6 → 122
    FAM177; FAM177 family

  2. NM_001394345.1 → NP_001381274.1  protein FAM177B

    Status: VALIDATED

    Source sequence(s)
    AL392172
    Consensus CDS
    CCDS1535.2
    UniProtKB/Swiss-Prot
    A6PVY3, Q6ZUN8
    Related
    ENSP00000414451.2, ENST00000445590.4
    Conserved Domains (1) summary
    pfam14774
    Location:6 → 122
    FAM177; FAM177 family

  3. NM_207468.3 → NP_997351.2  protein FAM177B

    See identical proteins and their annotated locations for NP_997351.2

    Status: VALIDATED

    Source sequence(s)
    AL392172, CA848039
    Consensus CDS
    CCDS1535.2
    UniProtKB/Swiss-Prot
    A6PVY3, Q6ZUN8
    Conserved Domains (1) summary
    pfam14774
    Location:6 → 122
    FAM177; FAM177 family

RNA

  1. NR_136691.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK125494, AL392172
    Related
    ENST00000391880.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    222737202..222751004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420602.1 → XP_047276558.1  protein FAM177B isoform X1

  2. XM_017001283.2 → XP_016856772.1  protein FAM177B isoform X3

  3. XM_017001284.2 → XP_016856773.1  protein FAM177B isoform X4

  4. XM_017001281.2 → XP_016856770.1  protein FAM177B isoform X2

    UniProtKB/Swiss-Prot
    A6PVY3, Q6ZUN8
    Conserved Domains (1) summary
    pfam14774
    Location:6 → 122
    FAM177; FAM177 family

  5. XM_017001279.2 → XP_016856768.1  protein FAM177B isoform X2

    UniProtKB/Swiss-Prot
    A6PVY3, Q6ZUN8
    Conserved Domains (1) summary
    pfam14774
    Location:6 → 122
    FAM177; FAM177 family

  6. XM_017001282.2 → XP_016856771.1  protein FAM177B isoform X2

    UniProtKB/Swiss-Prot
    A6PVY3, Q6ZUN8
    Conserved Domains (1) summary
    pfam14774
    Location:6 → 122
    FAM177; FAM177 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    221970958..221984766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336590.1 → XP_054192565.1  protein FAM177B isoform X1

  2. XM_054336593.1 → XP_054192568.1  protein FAM177B isoform X4

  3. XM_054336592.1 → XP_054192567.1  protein FAM177B isoform X3

  4. XM_054336591.1 → XP_054192566.1  protein FAM177B isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6PVY3.1 GenPept UniProtKB/Swiss-Prot:A6PVY3

Gene LinkOut

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