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lush lush [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40136, updated on 2-Nov-2024

Summary

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Official Symbol
lushprovided by FlyBase
Official Full Name
lushprovided by FlyBase
Primary source
FLYBASE:FBgn0020277
Locus tag
Dmel_CG8807
See related
AllianceGenome:FB:FBgn0020277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
76a; 76c; 76c(LUSH); CG8807; DmelObp76a; DmelOBP76a; Dmel\CG8807; Lush; LUSH; OBP LUSH; obp76a; Obp76a; OBP76a; Obp76a (LUSH)
Summary
Enables dibutyl phthalate binding activity and diphenyl phthalate binding activity. Involved in several processes, including courtship behavior; olfactory behavior; and sensory perception of smell. Located in extracellular region. Is expressed in antenna; antennal sense organ; eo sensory organ accessory cell; and trichoid sensillum. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See lush in Genome Data Viewer
Location:
76B9-76B9; 3-45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19604398..19606090, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19597498..19599190, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene TBP-associated factor 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lon protease Neighboring gene lethal (3) 76BDm Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nanoporous MoS(2) Field-Effect Transistor Based Artificial Olfaction: Achieving Enhanced Volatile Organic Compound Detection Inspired by the Drosophila Olfactory System. Shim J, et al. ACS Nano, 2023 Nov 14. PMID 37902651
  2. Quantitative analysis of pheromone-binding protein specificity. Katti S, et al. Insect Mol Biol, 2013 Feb. PMID 23121132, Free PMC Article
  3. Odorant binding protein based biomimetic sensors for detection of alcohols associated with Salmonella contamination in packaged beef. Sankaran S, et al. Biosens Bioelectron, 2011 Mar 15. PMID 21227678
  4. Alcohol binding to the odorant binding protein LUSH: multiple factors affecting binding affinities. Ader L, et al. Biochemistry, 2010 Jul 27. PMID 20550105, Free PMC Article
  5. The role of multiple hydrogen-bonding groups in specific alcohol binding sites in proteins: insights from structural studies of LUSH. Thode AB, et al. J Mol Biol, 2008 Mar 7. PMID 18234222, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An angiotensin converting enzyme homolog is required for volatile pheromone detection, odorant binding protein secretion and normal courtship behavior in Drosophila melanogaster.
    Title: An angiotensin converting enzyme homolog is required for volatile pheromone detection, odorant binding protein secretion and normal courtship behavior in Drosophila melanogaster.
  2. the ligand-binding cavity of LUSH protein can accommodate a variety ligands and pheromones with strong binding interactions
    Title: Quantitative analysis of pheromone-binding protein specificity.
  3. the alcohol binding in the LUSH protein is the consequence of three important factors: H-bonding, solvation, and the other noncovalent interaction.
    Title: Alcohol binding to the odorant binding protein LUSH: multiple factors affecting binding affinities.
  4. Detection of odorants by olfactory neurons is results from direct activation of odorant receptors by odor molecules; study shows that detection of the 11-cis vaccenyl acetate (cVA), is instead mediated by pheromone-induced conformational shifts in LUSH.
    Title: Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding protein.
  5. genetic interaction between lush and spontaneous activity in 11-cis vaccenyl acetate-sensitive neurons in the absence of pheromone
    Title: Drosophila OBP LUSH is required for activity of pheromone-sensitive neurons.
  6. LUSH, a soluble odorant-binding protein, undergoes a major conformational change, triggered by ligands.
    Title: Revisiting the odorant-binding protein LUSH of Drosophila melanogaster: evidence for odour recognition and discrimination.
  7. Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster
    Title: Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dibutyl phthalate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dibutyl phthalate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables diphenyl phthalate binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables ethanol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables odorant binding IEA
Inferred from Electronic Annotation
more info
  
enables odorant binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables odorant binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in olfactory behavior IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in olfactory behavior IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in olfactory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in response to ethanol IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to ethanol TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to pheromone IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lush
Names
CG8807-PA
CG8807-PB
LUSH
lush-PA
lush-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19604398..19606090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079438.3 → NP_524162.1  lush, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524162.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JI39, O02372, Q29QG4
    UniProtKB/TrEMBL
    A0A1B2AJ65
    Related
    FBpp0074737
    Conserved Domains (1) summary
    smart00708
    Location:42 → 145
    PhBP; Insect pheromone/odorant binding protein domains

  2. NM_001169997.1 → NP_001163468.1  lush, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163468.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JI39, O02372, Q29QG4
    UniProtKB/TrEMBL
    A0A1B2AJ65
    Conserved Domains (1) summary
    smart00708
    Location:42 → 145
    PhBP; Insect pheromone/odorant binding protein domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O02372.1 O02372

Gene LinkOut

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