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RAB19 RAB19, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 401409, updated on 2-Nov-2024

Summary

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Official Symbol
RAB19provided by HGNC
Official Full Name
RAB19, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:19982
See related
Ensembl:ENSG00000146955 AllianceGenome:HGNC:19982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAB19B
Summary
Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly and intracellular protein transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in colon (RPKM 1.1), thyroid (RPKM 1.0) and 15 other tissues See more
Orthologs
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Genomic context

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See RAB19 in Genome Data Viewer
Location:
7q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (140404058..140427974)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (141718006..141742144)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (140103858..140127774)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene solute carrier family 37 member 3 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26779 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:140089807-140090308 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:140090309-140090808 Neighboring gene RNA, 5S ribosomal pseudogene 248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18711 Neighboring gene uncharacterized LOC124901759 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140103431-140103932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140103933-140104432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26781 Neighboring gene nucleoside diphosphate kinase, mitochondrial-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140143760-140144260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:140156257-140157110 Neighboring gene makorin ring finger protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:140178571-140179411

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis.
    Title: WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis.
  2. N6-methyladenosine (m6A)-mediated up-regulation of long noncoding RNA LINC01320 promotes the proliferation, migration, and invasion of gastric cancer via miR495-5p/RAB19 axis.
    Title: N6-methyladenosine (m6A)-mediated up-regulation of long noncoding RNA LINC01320 promotes the proliferation, migration, and invasion of gastric cancer via miR495-5p/RAB19 axis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein Rab-19
Names
GTP-binding protein RAB19B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008749.3 → NP_001008749.2  ras-related protein Rab-19

    See identical proteins and their annotated locations for NP_001008749.2

    Status: VALIDATED

    Source sequence(s)
    AC069335, BC140796, DN996121, DY655778
    Consensus CDS
    CCDS34762.2
    UniProtKB/Swiss-Prot
    A4D1S5, A4D1S6, B2RTS6, B5MDR2, Q9UL27
    Related
    ENSP00000440167.1, ENST00000537763.6
    Conserved Domains (1) summary
    cd01864
    Location:15 → 179
    Rab19; Rab GTPase family 19 (Rab19)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    140404058..140427974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249997.4 → XP_005250054.1  ras-related protein Rab-19 isoform X2

    Conserved Domains (2) summary
    cd01864
    Location:15 → 167
    Rab19; Rab GTPase family 19 (Rab19)
    smart00175
    Location:18 → 170
    RAB; Rab subfamily of small GTPases

  2. XM_005249998.4 → XP_005250055.1  ras-related protein Rab-19 isoform X3

    Conserved Domains (2) summary
    smart00175
    Location:18 → 168
    RAB; Rab subfamily of small GTPases
    cl21455
    Location:15 → 165
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_005249996.4 → XP_005250053.1  ras-related protein Rab-19 isoform X1

    See identical proteins and their annotated locations for XP_005250053.1

    UniProtKB/Swiss-Prot
    A4D1S5, A4D1S6, B2RTS6, B5MDR2, Q9UL27
    Related
    ENSP00000348778.3, ENST00000356407.3
    Conserved Domains (1) summary
    cd01864
    Location:15 → 179
    Rab19; Rab GTPase family 19 (Rab19)

  4. XM_047420375.1 → XP_047276331.1  ras-related protein Rab-19 isoform X2

  5. XM_017012207.2 → XP_016867696.1  ras-related protein Rab-19 isoform X1

    UniProtKB/Swiss-Prot
    A4D1S5, A4D1S6, B2RTS6, B5MDR2, Q9UL27
    Conserved Domains (1) summary
    cd01864
    Location:15 → 179
    Rab19; Rab GTPase family 19 (Rab19)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    141718006..141742144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358219.1 → XP_054214194.1  ras-related protein Rab-19 isoform X2

  2. XM_054358216.1 → XP_054214191.1  ras-related protein Rab-19 isoform X1

    UniProtKB/Swiss-Prot
    A4D1S5, A4D1S6, B2RTS6, B5MDR2, Q9UL27

  3. XM_054358218.1 → XP_054214193.1  ras-related protein Rab-19 isoform X2

  4. XM_054358220.1 → XP_054214195.1  ras-related protein Rab-19 isoform X3

  5. XM_054358217.1 → XP_054214192.1  ras-related protein Rab-19 isoform X1

    UniProtKB/Swiss-Prot
    A4D1S5, A4D1S6, B2RTS6, B5MDR2, Q9UL27
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4D1S5.2 GenPept UniProtKB/Swiss-Prot:A4D1S5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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