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IFITM10 interferon induced transmembrane protein 10 [ Homo sapiens (human) ]

Gene ID: 402778, updated on 5-Mar-2024

Summary

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Official Symbol
IFITM10provided by HGNC
Official Full Name
interferon induced transmembrane protein 10provided by HGNC
Primary source
HGNC:HGNC:40022
See related
Ensembl:ENSG00000244242 MIM:618293; AllianceGenome:HGNC:40022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DSPA3
Summary
Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal (RPKM 13.9), brain (RPKM 6.2) and 11 other tissues See more
Orthologs
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Genomic context

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Location:
11p15.5
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1732406..1750595, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1817953..1836145, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1753636..1771825, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2708 Neighboring gene keratin associated protein 5-6 Neighboring gene skeletal muscle cis-regulatory module in IFITM10 intron Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1770125-1770880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1770881-1771636 Neighboring gene cathepsin D Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3058 Neighboring gene PRC2 and DDX5 associated lncRNA Neighboring gene uncharacterized LOC105376517

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. Sällman Almén M, et al. PLoS One, 2012. PMID 22363774, Free PMC Article
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. Taylor TD, et al. Nature, 2006 Mar 23. PMID 16554811
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: CTSD

Homology

Clone Names

  • FLJ12231, FLJ76511

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon-induced transmembrane protein 10
Names
dispanin subfamily A member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170820.4 → NP_001164291.2  interferon-induced transmembrane protein 10

    See identical proteins and their annotated locations for NP_001164291.2

    Status: VALIDATED

    Source sequence(s)
    AC068580, BQ183689, BQ669640, DB219779
    Consensus CDS
    CCDS53593.2
    UniProtKB/Swiss-Prot
    A6NEU7, A6NMD0
    Related
    ENSP00000344430.4, ENST00000340134.5
    Conserved Domains (1) summary
    pfam04505
    Location:145 → 216
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    1732406..1750595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187657.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    206152..209195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    1817953..1836145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NMD0.1 GenPept UniProtKB/Swiss-Prot:A6NMD0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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