cnpy1 canopy FGF signaling regulator 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cnpy1provided by ZNC
Official Full Name: canopy FGF signaling regulator 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060315-3
See related: Ensembl:ENSDARG00000003757 AllianceGenome:ZFIN:ZDB-GENE-060315-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Acts upstream of or within several processes, including Kupffer's vesicle development; midbrain-hindbrain boundary development; and regulation of fibroblast growth factor receptor signaling pathway. Located in endoplasmic reticulum. Is expressed in several structures, including forerunner cell group; margin; midbrain hindbrain boundary; midbrain hindbrain boundary neural rod; and polster. Orthologous to human CNPY1 (canopy FGF signaling regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (29986262..29996045, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (30002729..30012512, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that positive feedback regulation of FGF signaling by Canopy1 (Cnpy1) controls DFC clustering.
Title: Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis.
saposin-related protein, expressed specifically in the midbrain-hindbrain boundary of zebrafish embryos
Title: Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within midbrain-hindbrain boundary development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein canopy-1

Names: D121 protein; canopy1

NP_001034586.1

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.