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PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial [ Sus scrofa (pig) ]

Gene ID: 403165, updated on 17-Aug-2024

Summary

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Official Symbol
PCK2provided by VGNC
Official Full Name
phosphoenolpyruvate carboxykinase 2, mitochondrialprovided by VGNC
Primary source
VGNC:VGNC:91223
See related
Ensembl:ENSSSCG00000002009
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
PEPCK
Expression
Biased expression in liver (RPKM 217.6), kidney (RPKM 204.3) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See PCK2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 7 NC_010449.5 (75187195..75197613, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 7 NC_010449.4 (80458494..80468914, complement)

Chromosome 7 - NC_010449.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110261592 Neighboring gene fat storage inducing transmembrane protein 1 Neighboring gene DDB1 and CUL4 associated factor 11 Neighboring gene neural retina leucine zipper Neighboring gene copine 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Concurrent binding and modifications of AUF1 and HuR mediate the pH-responsive stabilization of phosphoenolpyruvate carboxykinase mRNA in kidney cells. Gummadi L, et al. Am J Physiol Renal Physiol, 2012 Dec 1. PMID 23019227, Free PMC Article
  2. Porcine gene discovery by normalized cDNA-library sequencing and EST cluster assembly. Fahrenkrug SC, et al. Mamm Genome, 2002 Aug. PMID 12226715
  3. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Concurrent binding and modifications of AUF1 and HuR mediate the pH-responsive stabilization of phosphoenolpyruvate carboxykinase mRNA in kidney cells.
    Title: Concurrent binding and modifications of AUF1 and HuR mediate the pH-responsive stabilization of phosphoenolpyruvate carboxykinase mRNA in kidney cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphoenolpyruvate carboxykinase (GTP) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycerol biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hepatocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in propionate catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to starvation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphoenolpyruvate carboxykinase [GTP], mitochondrial
NP_001155225.1
XP_020953977.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161753.1 → NP_001155225.1  phosphoenolpyruvate carboxykinase [GTP], mitochondrial

    See identical proteins and their annotated locations for NP_001155225.1

    Status: VALIDATED

    Source sequence(s)
    AK233595, BG610484, DB809833
    UniProtKB/TrEMBL
    A0A4X1SLW9, A0A8D0NCY0, C5I4T6
    Related
    ENSSSCP00000078571.1, ENSSSCT00000104693.1
    Conserved Domains (1) summary
    cd00819
    Location:44 → 633
    PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010449.5 Reference Sscrofa11.1 Primary Assembly

    Range
    75187195..75197613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021098318.1 → XP_020953977.1  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A4X1SKP7, A0A4X1SLX9, A0A8D0N7R1
    Conserved Domains (1) summary
    cd00819
    Location:1 → 499
    PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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