U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Defb21 defensin beta 21 [ Mus musculus (house mouse) ]

Gene ID: 403172, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Defb21provided by MGI
Official Full Name
defensin beta 21provided by MGI
Primary source
MGI:MGI:2684967
See related
Ensembl:ENSMUSG00000056544 AllianceGenome:MGI:2684967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm121; 4930525K10Rik
Summary
Predicted to enable lipopolysaccharide binding activity and membrane destabilizing activity. Predicted to be involved in several processes, including defense response to other organism; killing of cells of another organism; and negative regulation of lipopolysaccharide-mediated signaling pathway. Is expressed in forelimb bud. Orthologous to human DEFB118 (defensin beta 118). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward genital fat pad adult (RPKM 67.6) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Defb21 in Genome Data Viewer
Location:
2 H1; 2 75.31 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152414663..152416864)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152572743..152574944)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene defensin beta 29 Neighboring gene predicted gene 14161 Neighboring gene STARR-seq mESC enhancer starr_06064 Neighboring gene predicted gene, 17416 Neighboring gene defensin beta 19 Neighboring gene defensin beta 45

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Patil AA, et al. Physiol Genomics, 2005 Sep 21. PMID 16033865
  2. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
  
enables membrane destabilizing activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in killing of cells of another organism ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
beta-defensin 118

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379477.1 → NP_001366406.1  beta-defensin 118 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5 UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL845162
    UniProtKB/TrEMBL
    Q2F9P8, Q8C5Z4
    Conserved Domains (1) summary
    pfam13841
    Location:33 → 62
    Defensin_beta_2; Beta defensin

  2. NM_207276.3 → NP_997159.1  beta-defensin 118 precursor

    See identical proteins and their annotated locations for NP_997159.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL845162
    Consensus CDS
    CCDS16890.1
    UniProtKB/TrEMBL
    Q2F9P8, Q8C5Z4
    Related
    ENSMUSP00000065102.3, ENSMUST00000070722.3
    Conserved Domains (1) summary
    pfam13841
    Location:33 → 62
    Defensin_beta_2; Beta defensin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152414663..152416864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous