TACR1 tachykinin receptor 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: TACR1provided by VGNC
Official Full Name: tachykinin receptor 1provided by VGNC
Primary source: VGNC:VGNC:47066
See related: Ensembl:ENSCAFG00845016647
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	17	NC_051821.1 (48900538..49041473)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	17	NC_006599.4 (47681510..47821826)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	17	NC_049238.1 (48542868..48683479)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	17	NC_049277.1 (47916025..48056577)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	17	NC_049758.1 (47980726..48121228)

Chromosome 17 - NC_051821.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study showed that, while maropitant inhibited proliferation and enhanced apoptosis in cell lines, in the absence of documented NK-1R expression, this may represent off-target effects; maropitant also failed to suppress tumour growth in a canine mouse xenograft model.
Title: Neurokinin-1 receptor expression and antagonism by the NK-1R antagonist maropitant in canine melanoma cell lines and primary tumour tissues.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables substance P receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of flagellated sperm motility	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in sperm midpiece	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: substance-P receptor

Names: NK-1 receptor; NK-1R; SPR; neurokinin receptor subtype NK1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012619.1 → NP_001012637.1 substance-P receptor

See identical proteins and their annotated locations for NP_001012637.1

Status: PROVISIONAL

Source sequence(s)

AJ884915

UniProtKB/Swiss-Prot

Q5DUB3

UniProtKB/TrEMBL

A0A8C0R0R9, A0A8P0SDI4

Related

ENSCAFP00845023180.1, ENSCAFT00845029508.1

Conserved Domains (1) summary

cd16002
Location:33 → 316

7tmA_NK1R; neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors