MYC MYC proto-oncogene, bHLH transcription factor [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MYCprovided by VGNC
Official Full Name: MYC proto-oncogene, bHLH transcription factorprovided by VGNC
Primary source: VGNC:VGNC:43527
See related: Ensembl:ENSCAFG00845012475
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: MRTL; MYCC; C-MYC; v-myc; bHLHe39
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	13	NC_051817.1 (25544697..25549239)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	13	NC_006595.4 (25169176..25173718)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	13	NC_049234.1 (25629077..25633621)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	13	NC_049273.1 (25260451..25264991)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	13	NC_049754.1 (25374618..25379158)

Chromosome 13 - NC_051817.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data presented here suggest that cobalamin deficiency in Shar Peis is not related to any mutations of the MYC_CANFA gene according to the genotyping and sequencing results in this study.
Title: Evaluation of the MYC_CANFA gene in Chinese Shar Peis with cobalamin deficiency.
study shows decorin blocks several biological activities mediated by Met signaling axis; these effects were mediated by downregulation of noncanonical beta-catenin levels; Myc was downregulated by decorin; phosphorylation of Myc at threonine 58 was induced
Title: Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
Eyelid and third eyelid tumors of dogs express both the p53 and the c-Myc genes as shown by PCR and RT-PCR.
Title: Occurrence and expression of p53 suppressor gene and c-Myc oncogene in dog eyelid tumors.

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General gene information

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Markers

PMC156147P1 (e-PCR)
- UniSTS:271368

G15987 (e-PCR)
- UniSTS:68875

MYC (e-PCR), detects polymorphism
- UniSTS:504377

Myc (e-PCR), detects polymorphism
- UniSTS:256954

PMC150726P9 (e-PCR)
- UniSTS:271081

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: myc proto-oncogene protein

Names: c-myc proto-oncogene; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003246.2 → NP_001003246.2 myc proto-oncogene protein

Status: VALIDATED

Source sequence(s)

AW784633, DN374130, DN392612, JAAUVH010000361, X95367

UniProtKB/Swiss-Prot

Q28350

UniProtKB/TrEMBL

A0A8C0Z0H4, A0A8I3NLI9

Related

ENSCAFP00845017481.1, ENSCAFT00845022232.1

Conserved Domains (3) summary

cd00083
Location:365 → 424

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam01056
Location:19 → 358

Myc_N; Myc amino-terminal region

pfam02344
Location:421 → 450

Myc-LZ; Myc leucine zipper domain