Prkcz2 protein kinase C, zeta 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prkcz2provided by MGI
Official Full Name: protein kinase C, zeta 2provided by MGI
Primary source: MGI:MGI:3029152
See related: AllianceGenome:MGI:3029152
Gene type: pseudo
RefSeq status: INFERRED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1839; Prkczl
Summary: Acts upstream of or within apical junction assembly. Located in bicellular tight junction and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 7 A3; 7 15.97 cM

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (27581824..27584046, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (27882399..27884621, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results indicate that pVHL recruits PKCzetaII via its PB1 domain and causes ubiquitination and degradation via the distal C-terminus of PKCzetaII.
Title: PKCzetaII is a target for degradation through the tumour suppressor protein pVHL.

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General gene information

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Markers

Prkcz (e-PCR), detects polymorphism
- UniSTS:472840

Prkcz (e-PCR), detects polymorphism
- UniSTS:507178

Prkcz (e-PCR), detects polymorphism
- UniSTS:144201

Prkcz (e-PCR), detects polymorphism
- UniSTS:507995

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apical junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.