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Krt87 keratin 87 [ Mus musculus (house mouse) ]

Gene ID: 406219, updated on 2-Nov-2024

Summary

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Official Symbol
Krt87provided by MGI
Official Full Name
keratin 87provided by MGI
Primary source
MGI:MGI:3665486
See related
Ensembl:ENSMUSG00000047641 AllianceGenome:MGI:3665486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K83; K87; Krt83; Krt2-25
Summary
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in breast cancer; erythrokeratodermia variabilis et progressiva 5; hair disease; and monilethrix. Orthologous to several human genes including KRT81 (keratin 81); KRT83 (keratin 83); and KRT86 (keratin 86). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 1.7), ovary adult (RPKM 0.8) and 11 other tissues See more
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Genomic context

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See Krt87 in Genome Data Viewer
Location:
15 F2; 15 56.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101329371..101336685, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101431490..101438804, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35853 Neighboring gene predicted gene 671 Neighboring gene STARR-seq mESC enhancer starr_39796 Neighboring gene keratin 7 Neighboring gene keratin 88 Neighboring gene keratin 81

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. Jheon AH, et al. J Cell Sci, 2011 Mar 1. PMID 21285247, Free PMC Article
  2. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article
  3. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, et al. Eur J Cell Biol, 2004 Feb. PMID 15085952
  4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
  
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
keratin, type II cuticular 87
Names
keratin complex 2, basic, gene 25
keratin, type II cuticular Hb3
keratin-83
type II hair keratin Hb3
type-II keratin Kb23
type-II keratin Kb25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003668.2 → NP_001003668.2  keratin, type II cuticular 87

    See identical proteins and their annotated locations for NP_001003668.2

    Status: VALIDATED

    Source sequence(s)
    AA755006, BC139321
    Consensus CDS
    CCDS27852.1
    UniProtKB/Swiss-Prot
    B2RTF5, Q6IMF0
    UniProtKB/TrEMBL
    Q61726
    Related
    ENSMUSP00000080613.4, ENSMUST00000081945.5
    Conserved Domains (3) summary
    pfam00038
    Location:110 → 421
    Filament; Intermediate filament protein
    pfam16208
    Location:4 → 107
    Keratin_2_head; Keratin type II head
    cl23720
    Location:320 → 388
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101329371..101336685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IMF0.2 GenPept UniProtKB/Swiss-Prot:Q6IMF0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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