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Krt77 keratin 77 [ Mus musculus (house mouse) ]

Gene ID: 406220, updated on 2-Nov-2024

Summary

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Official Symbol
Krt77provided by MGI
Official Full Name
keratin 77provided by MGI
Primary source
MGI:MGI:3588209
See related
Ensembl:ENSMUSG00000067594 AllianceGenome:MGI:3588209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K77; mK1b; CK-1B; K1emb; Krt239; 4732484G22Rik
Summary
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Is active in cornified envelope. Is expressed in epidermis; palmar pad; and skin. Orthologous to human KRT77 (keratin 77). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in mammary gland adult (RPKM 6.1), limb E14.5 (RPKM 5.5) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Krt77 in Genome Data Viewer
Location:
15 F2; 15 57.08 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101767166..101778141, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101858731..101869706, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35972 Neighboring gene keratin 1 Neighboring gene STARR-seq mESC enhancer starr_39807 Neighboring gene keratin 76 Neighboring gene keratin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of a coding sequence for a novel type II keratin from N-terminal sequences of mouse epidermal proteins site-specifically deiminated in embryonic development. Senshu T, et al. J Dermatol Sci, 2005 Jan. PMID 15619433
  2. Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression. Bazzi H, et al. Dev Dyn, 2007 Apr. PMID 17330888
  3. Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23. Madon-Simon M, et al. PLoS One, 2017. PMID 28650975, Free PMC Article
  4. The mineralocorticoid receptor plays a transient role in mouse skin development. Boix J, et al. Exp Dermatol, 2016 Jan. PMID 26268211
  5. Glucocorticoid receptor regulates overlapping and differential gene subsets in developing and adult skin. Sevilla LM, et al. Mol Endocrinol, 2010 Nov. PMID 20880987, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Krt77 is the highest expressed gene among keratins in epidermis embryonic development.
    Title: Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression.
  2. sequence of novel type II keratin site-specifically deiminated in embryonic mouse epidermis.
    Title: Prediction of a coding sequence for a novel type II keratin from N-terminal sequences of mouse epidermal proteins site-specifically deiminated in embryonic development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
keratin, type II cytoskeletal 1b
Names
cytokeratin-1B
embryonic type II keratin 1
keratin 1b
keratin complex 2, basic, gene 39
type II keratin Kb39
type-II intermediate filament protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003667.2 → NP_001003667.1  keratin, type II cytoskeletal 1b

    See identical proteins and their annotated locations for NP_001003667.1

    Status: VALIDATED

    Source sequence(s)
    AA880500, AC104862, AK132513, BK003993
    Consensus CDS
    CCDS27865.1
    UniProtKB/Swiss-Prot
    Q6IFZ6
    UniProtKB/TrEMBL
    Q08EK4, Q08EK5
    Related
    ENSMUSP00000085311.6, ENSMUST00000087996.7
    Conserved Domains (2) summary
    pfam00038
    Location:166 → 479
    Filament; Intermediate filament protein
    pfam16208
    Location:51 → 163
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101767166..101778141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521140.1 → XP_006521203.1  keratin, type II cytoskeletal 1b isoform X1

    UniProtKB/TrEMBL
    Q08EK4
    Conserved Domains (2) summary
    pfam00038
    Location:166 → 479
    Filament; Intermediate filament protein
    pfam16208
    Location:51 → 163
    Keratin_2_head; Keratin type II head

  2. XM_017316690.1 → XP_017172179.1  keratin, type II cytoskeletal 1b isoform X2

    Conserved Domains (1) summary
    pfam00038
    Location:1 → 234
    Filament; Intermediate filament protein

  3. XM_030248628.1 → XP_030104488.1  keratin, type II cytoskeletal 1b isoform X3

    Conserved Domains (1) summary
    pfam00038
    Location:1 → 234
    Filament; Intermediate filament protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IFZ6.1 GenPept UniProtKB/Swiss-Prot:Q6IFZ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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