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acadm acyl-CoA dehydrogenase medium chain [ Danio rerio (zebrafish) ]

Gene ID: 406283, updated on 12-Sep-2024

Summary

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Official Symbol
acadmprovided by ZNC
Official Full Name
acyl-CoA dehydrogenase medium chainprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1945
See related
Ensembl:ENSDARG00000038900 AllianceGenome:ZFIN:ZDB-GENE-040426-1945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MCAD; fb53e01; zgc:56101; zgc:76911; wu:fb53e01; zgc:111905
Summary
Predicted to enable medium-chain-acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation and medium-chain fatty acid catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in female organism and liver. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See acadm in Genome Data Viewer
Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (26470070..26476119, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (26814436..26820485, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene ephrin-A2a Neighboring gene uncharacterized LOC137487824 Neighboring gene Rab geranylgeranyltransferase subunit beta Neighboring gene HECT domain containing 3 Neighboring gene small nucleolar RNA SNORD46 Neighboring gene ribosomal protein S8a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Inhibitory Effects of Mongolian Medicine Yihe-Tang on Continuous Darkness Induced Liver Steatosis in Zebrafish. Sa R, et al. Evid Based Complement Alternat Med, 2022. PMID 35646144, Free PMC Article
  2. Differential mitochondrial dysregulation by exposure to individual organochlorine pesticides (OCPs) and their mixture in zebrafish embryos. Lee H, et al. Environ Pollut, 2021 May 15. PMID 33714130
  3. Enantioselective bioaccumulation following exposure of adult zebrafish (Danio rerio) to epoxiconazole and its effects on metabolomic profile as well as genes expression. Wang Y, et al. Environ Pollut, 2017 Oct. PMID 28601015
  4. Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish. Hasumura T, et al. Nutr Metab (Lond), 2012 Aug 7. PMID 22871059, Free PMC Article
  5. Temporal and spatial patterns of gene expression in skeletal muscles in response to swim training in adult zebrafish (Danio rerio). LeMoine CM, et al. J Comp Physiol B, 2010 Jan. PMID 19693513

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables medium-chain fatty acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables medium-chain fatty acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in medium-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Names
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain
NP_998175.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213010.2 → NP_998175.2  medium-chain specific acyl-CoA dehydrogenase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    DT082054, EB765156, EH563476, EH601638
    UniProtKB/TrEMBL
    A0A8M1PII2, A2CG95
    Related
    ENSDARP00000117024.1, ENSDART00000132125.3
    Conserved Domains (2) summary
    cd01157
    Location:46 → 423
    MCAD; Medium chain acyl-CoA dehydrogenase
    COG1960
    Location:44 → 426
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    26470070..26476119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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