MIR219A1 microRNA 219a-1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR219A1provided by HGNC
Official Full Name: microRNA 219a-1provided by HGNC
Primary source: HGNC:HGNC:31597
See related: Ensembl:ENSG00000199036 MIM:611500; miRBase:MI0000296; AllianceGenome:HGNC:31597
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: mir-219; MIR219-1; MRI219-1; MIRN219-1; mir-219a-1; hsa-mir-219a-1
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 6p21.32

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (33207835..33207944)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (33029188..33029297)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (33175612..33175721)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Investigation of the effects of mir-219-1 gene variants on the development of disease in non-small cell lung cancer patients.
Title: Investigation of the effects of mir-219-1 gene variants on the development of disease in non-small cell lung cancer patients.
Down-regulation of miR-219-5p increase the risk of cancer-related mortality in patients with prostate cancer.
Title: Down-regulation of miR-219-5p increase the risk of cancer-related mortality in patients with prostate cancer.
CircPRKCI regulates proliferation, migration and cycle of lung adenocarcinoma cells by targeting miR-219a-5p-regulated CAMK1D.
Title: CircPRKCI regulates proliferation, migration and cycle of lung adenocarcinoma cells by targeting miR-219a-5p-regulated CAMK1D.
MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha.
Title: MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha.
miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1.
Title: miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1.
Epigenetic Modification of MicroRNA-219-1 and Its Association with Glioblastoma Multiforme.
Title: Epigenetic Modification of MicroRNA-219-1 and Its Association with Glioblastoma Multiforme.
miR-219a suppresses human trophoblast cell invasion and proliferation by targeting vascular endothelial growth factor receptor 2 (VEGFR2).
Title: miR-219a suppresses human trophoblast cell invasion and proliferation by targeting vascular endothelial growth factor receptor 2 (VEGFR2).
MicroRNA-219 inhibits cell viability and metastasis in papillary thyroid carcinoma by targeting EYA2.
Title: MicroRNA-219 inhibits cell viability and metastasis in papillary thyroid carcinoma by targeting EYA2.
MiR-219-5p inhibits prostate cancer cell growth and metastasis by targeting HMGA2.
Title: MiR-219-5p inhibits prostate cancer cell growth and metastasis by targeting HMGA2.
miR-219a-5p enhances the radiosensitivity of non-small cell lung cancer cells through targeting CD164.
Title: miR-219a-5p enhances the radiosensitivity of non-small cell lung cancer cells through targeting CD164.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

SHGC-31083 (e-PCR)
- UniSTS:23851

D6S2731 (e-PCR)
- UniSTS:464434

MARC_5283-5284:991939549:1 (e-PCR)
- UniSTS:231147

MARC_5283-5284:996690262:1 (e-PCR)
- UniSTS:231147

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA base-pairing translational repressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info
involved_in miRNA-mediated post-transcriptional gene silencing	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of tau-protein kinase activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.