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TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough [ Homo sapiens (human) ]

Gene ID: 407977, updated on 5-Mar-2024

Summary

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Official Symbol
TNFSF12-TNFSF13provided by HGNC
Official Full Name
TNFSF12-TNFSF13 readthroughprovided by HGNC
Primary source
HGNC:HGNC:33537
See related
Ensembl:ENSG00000248871 AllianceGenome:HGNC:33537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TWE-PRIL
Summary
This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 41.7), gall bladder (RPKM 26.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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See TNFSF12-TNFSF13 in Genome Data Viewer
Location:
17p13.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7549058..7561601)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7453339..7465862)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7452375..7464918)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11623 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7386897-7387891 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7387892-7388885 Neighboring gene solute carrier family 35 member G6 Neighboring gene RNA polymerase II subunit A Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:7405086-7406285 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:7414586-7415785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7458208-7458708 Neighboring gene TNF superfamily member 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7460817-7461610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8128 Neighboring gene SENP3-EIF4A1 readthrough (NMD candidate) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7466006-7466702 Neighboring gene TNF superfamily member 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8130 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7476397-7477152 Neighboring gene SUMO specific peptidase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7477153-7477908 Neighboring gene eukaryotic translation initiation factor 4A1 Neighboring gene small nucleolar RNA, H/ACA box 48

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity. Krumbholz M, et al. Brain, 2008 Jun. PMID 18474519
  2. BAFF, APRIL, TWE-PRIL: who's who? Daridon C, et al. Autoimmun Rev, 2008 Feb. PMID 18295728
  3. TWE-PRIL; a fusion protein of TWEAK and APRIL. Kolfschoten GM, et al. Biochem Pharmacol, 2003 Oct 15. PMID 14555217
  4. Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers. Yang C, et al. Immunogenetics, 2012 Oct. PMID 22864923
  5. Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese. Kawasaki A, et al. Rheumatology (Oxford), 2007 May. PMID 17307753

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
EBI GWAS Catalog
Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese.
EBI GWAS Catalog
Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers.
EBI GWAS Catalog
Genome-wide scan identifies variant in TNFSF13 associated with serum IgM in a healthy Chinese male population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
TNFSF12-TNFSF13 protein
Names
tumor necrosis factor (ligand) superfamily, member 12-member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172089.4 → NP_742086.1  TNFSF12-TNFSF13 protein

    See identical proteins and their annotated locations for NP_742086.1

    Status: REVIEWED

    Source sequence(s)
    AC016876, AY081051
    UniProtKB/TrEMBL
    A0A0A6YY99
    Related
    ENSP00000293826.4, ENST00000293826.4
    Conserved Domains (2) summary
    cd00184
    Location:197 → 328
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    cl00147
    Location:131 → 166
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7549058..7561601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7453339..7465862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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