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Zfp873 zinc finger protein 873 [ Mus musculus (house mouse) ]

Gene ID: 408062, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp873provided by MGI
Official Full Name
zinc finger protein 873provided by MGI
Primary source
MGI:MGI:3040689
See related
Ensembl:ENSMUSG00000061371 AllianceGenome:MGI:3040689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 2.2), CNS E14 (RPKM 1.8) and 22 other tissues See more
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Genomic context

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See Zfp873 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81883918..81914461)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (82048084..82077727)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10630 Neighboring gene predicted gene, 46195 Neighboring gene sorting nexin family member 27 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2330 Neighboring gene cDNA sequence BC024063 Neighboring gene STARR-seq mESC enhancer starr_27356 Neighboring gene STARR-positive B cell enhancer ABC_E8351 Neighboring gene expressed sequence AU041133

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
  5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC102234

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 873

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024626.2 → NP_001019797.2  zinc finger protein 873 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate start codon and lacks an alternate exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC171183, AK143655
    Consensus CDS
    CCDS83738.1
    UniProtKB/TrEMBL
    E9PU88
    Related
    ENSMUSP00000100950.2, ENSMUST00000105313.2
    Conserved Domains (3) summary
    COG5048
    Location:121 → 536
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:473 → 498
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001319203.1 → NP_001306132.1  zinc finger protein 873 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC171183, BC090848
    Consensus CDS
    CCDS36009.2
    UniProtKB/TrEMBL
    A0A1B0GT64
    Related
    ENSMUSP00000148219.2, ENSMUST00000210325.2
    Conserved Domains (5) summary
    smart00349
    Location:4 → 45
    KRAB; krueppel associated box
    COG5048
    Location:158 → 573
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:510 → 535
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81883918..81914461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243504.4 → XP_011241806.1  zinc finger protein 873 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:158 → 573
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 44
    KRAB; KRAB box

  2. XM_011243505.2 → XP_011241807.1  zinc finger protein 873 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:158 → 573
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 44
    KRAB; KRAB box

  3. XM_017314022.2 → XP_017169511.1  zinc finger protein 873 isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:81 → 453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:386 → 406
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 44
    KRAB; KRAB box
    pfam13465
    Location:511 → 535
    zf-H2C2_2; Zinc-finger double domain

  4. XM_036155884.1 → XP_036011777.1  zinc finger protein 873 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:121 → 536
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_030245155.2 → XP_030101015.1  zinc finger protein 873 isoform X5

    Conserved Domains (2) summary
    COG5048
    Location:121 → 536
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_036155885.1 → XP_036011778.1  zinc finger protein 873 isoform X6

    Conserved Domains (3) summary
    COG5048
    Location:158 → 573
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 44
    KRAB; KRAB box
Nucleotide Protein Strain
Heading Accession and Version

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