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Mug2 murinoglobulin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 408236, updated on 28-Oct-2024

Summary

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Symbol
Mug2provided by RGD
Full Name
murinoglobulin 2provided by RGD
Primary source
RGD:1302962
See related
EnsemblRapid:ENSRNOG00000075610 AllianceGenome:RGD:1302962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in anterior segment dysgenesis 8. Orthologous to several human genes including PZP (PZP alpha-2-macroglobulin like). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward (RPKM 5552.5) See more
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Genomic context

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See Mug2 in Genome Data Viewer
Location:
4q42
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (156836140..156908972)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (155164061..155236894)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (154215262..154282608)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene murinoglobulin 1 Neighboring gene uncharacterized LOC108350756 Neighboring gene C3 and PZP-like, alpha-2-macroglobulin domain containing 8 Neighboring gene thymosin beta-10-like Neighboring gene uncharacterized LOC134486841

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure and negative transcriptional regulation by glucocorticoids of the acute-phase rat alpha 1-inhibitor III gene. Northemann W, et al. Biochemistry, 1989 Jan 10. PMID 2495816
  2. Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3. Enghild JJ, et al. J Biol Chem, 1989 Jul 5. PMID 2472396
  3. Mutations in CPAMD8 Cause a Unique Form of Autosomal-Recessive Anterior Segment Dysgenesis. Cheong SS, et al. Am J Hum Genet, 2016 Dec 1. PMID 27839872, Free PMC Article
  4. Sequence and acute phase regulation of rat alpha 1-inhibitor III messenger RNA. Braciak TA, et al. J Biol Chem, 1988 Mar 15. PMID 2831216
  5. Identification and sequencing of cDNA clones for the rodent negative acute-phase protein alpha 1-inhibitor 3. Schweizer M, et al. Eur J Biochem, 1987 Apr 15. PMID 2436907

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
murinoglobulin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395728.1 → NP_001382657.1  murinoglobulin-2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AQK4
    Related
    ENSRNOP00000093643.2, ENSRNOT00000119571.2
    Conserved Domains (3) summary
    COG2373
    Location:760 → 1089
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd02897
    Location:974 → 1280
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    cl23771
    Location:365 → 414
    Big_1; Bacterial Ig-like domain (group 1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    156836140..156908972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107979.2 → XP_038963907.1  murinoglobulin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQK4
    Related
    ENSRNOP00000091322.1, ENSRNOT00000119344.2
    Conserved Domains (7) summary
    cd02897
    Location:974 → 1280
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:754 → 844
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129 → 221
    A2M_N; MG2 domain
    pfam07677
    Location:1392 → 1479
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:457 → 605
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:348 → 443
    MG4; Macroglobulin domain MG4
    pfam17791
    Location:223 → 309
    MG3; Macroglobulin domain MG3

  2. XM_039107980.2 → XP_038963908.1  murinoglobulin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQK4
    Conserved Domains (7) summary
    cd02897
    Location:903 → 1209
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:683 → 773
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:1321 → 1408
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:386 → 534
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:277 → 372
    MG4; Macroglobulin domain MG4
    pfam17791
    Location:152 → 238
    MG3; Macroglobulin domain MG3
    cl19929
    Location:94 → 150
    A2M_N; MG2 domain

  3. XM_063286427.1 → XP_063142497.1  murinoglobulin-2 isoform X3

  4. XM_063286428.1 → XP_063142498.1  murinoglobulin-2 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001002826.1: Suppressed sequence

    Description
    NM_001002826.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IE52.1 GenPept UniProtKB/Swiss-Prot:Q6IE52

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