rn rotund [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rnprovided by FlyBase
Official Full Name: rotundprovided by FlyBase
Primary source: FLYBASE:FBgn0267337
Locus tag: Dmel_CG42277
See related: AllianceGenome:FB:FBgn0267337
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5.3; CG10040; CG14600; CG14601; CG14603; CG32466; CG32467; CG42277; Dipr; Dmel\CG42277; P5.3; Rn; roe; tod; tot
Old locus tag: Dmel_CG32466; Dmel_CG32467
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including imaginal disc-derived leg morphogenesis; negative regulation of transcription by RNA polymerase II; and sensory organ development. Located in nucleus. Is expressed in several structures, including adepithelial cell of wing disc; adult antennal olfactory receptor neurons; embryonic/larval motor neurons; head segment; and imaginal disc. Orthologous to human ZNF362 (zinc finger protein 362). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 84D3-84D3; 3-48 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (7272617..7309629, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (3098339..3135351, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we find that C15 interacts physically with the Dll activator through contacts between their homeodomain and binds competitively with Dll to adjacent cognate sites on LAE, adding potential new layers of regulation by C15. Lastly, we show that C15 and Bowl activities regulate also rn expression
Title: Tissue-specific enhancer repression through molecular integration of cell signaling inputs.
Joint ectopic expression of Dll and Rn is sufficient to cell-autonomously activate endogenous bab2 and LAE-driven reporter expression in wing and haltere cells
Title: Drosophila distal-less and Rotund bind a single enhancer ensuring reliable and robust bric-a-brac2 expression in distinct limb morphogenetic fields.
Roe acts as a transcriptional repressor in a negative-feedback loop of the N pathway.
Title: Self-modulation of Notch signaling during ommatidial development via the Roughened eye transcriptional repressor.
Squeeze and Rotund are regulated by Nab and have roles in Drosophila development
Title: Nab controls the activity of the zinc-finger transcription factors Squeeze and Rotund in Drosophila development.
The Drosophila rotund gene codes for two distinct zinc finger proteins.
Title: Control of Drosophila imaginal disc development by rotund and roughened eye: differentially expressed transcripts of the same gene encoding functionally distinct zinc finger proteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IC Inferred by Curator more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: rotund

Names: CG42277-PC; CG42277-PE; CG42277-PF; CG42277-PG; Distal-into-proximal; T-one deficient; rn-PC; rn-PE; rn-PF; rn-PG; roughened eye; t-one transformed

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

7272617..7309629 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_141458.3 → NP_649715.2 rotund, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649715.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q4V6Z5, Q8WRV3, Q9VI90, Q9VI93

Related

FBpp0289745

Conserved Domains (4) summary

sd00017
Location:519 → 539

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:545 → 567

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:559 → 586

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:550 → 630

zf-C2H2_8; C2H2-type zinc ribbon
NM_001275414.2 → NP_001262343.1 rotund, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262343.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGD3

Conserved Domains (4) summary

sd00017
Location:519 → 539

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:545 → 567

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:559 → 586

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:550 → 630

zf-C2H2_8; C2H2-type zinc ribbon
NM_001144549.2 → NP_001138021.1 rotund, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138021.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0U8

Conserved Domains (4) summary

sd00017
Location:500 → 520

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:526 → 548

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:540 → 567

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:531 → 611

zf-C2H2_8; C2H2-type zinc ribbon
NM_206456.2 → NP_996178.1 rotund, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996178.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VI93

Conserved Domains (4) summary

sd00017
Location:265 → 285

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:291 → 313

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:305 → 332

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:296 → 376

zf-C2H2_8; C2H2-type zinc ribbon