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MAGEA3 MAGE family member A3 [ Homo sapiens (human) ]

Gene ID: 4102, updated on 2-Nov-2024

Summary

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Official Symbol
MAGEA3provided by HGNC
Official Full Name
MAGE family member A3provided by HGNC
Primary source
HGNC:HGNC:6801
See related
Ensembl:ENSG00000221867 MIM:300174; AllianceGenome:HGNC:6801
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIP8; HYPD; CT1.3; MAGE3; MAGEA6
Summary
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 4.8) See more
Orthologs
all
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Genomic context

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See MAGEA3 in Genome Data Viewer
Location:
Xq28
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (152698794..152702347)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (150965367..150968920)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151867272..151870825)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGEA3 divergent transcript Neighboring gene gamma-aminobutyric acid type A receptor subunit theta Neighboring gene MAGE family member A4 pseudogene Neighboring gene uncharacterized LOC124905224 Neighboring gene CSAG family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evaluation of melanoma antigen gene A3 expression in drug resistance of epidermal growth factor receptor-tyrosine kinase inhibitors in advanced nonsmall cell lung cancer treatment. Jin J, et al. J Cancer Res Ther, 2015 Nov. PMID 26612451
  2. Endosomal proteases influence the repertoire of MAGE-A3 epitopes recognized in vivo by CD4+ T cells. Marturano J, et al. Cancer Res, 2008 Mar 1. PMID 18316621
  3. Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3. Lu YC, et al. J Clin Oncol, 2017 Oct 10. PMID 28809608, Free PMC Article
  4. Fibroblast growth factor 2 and estrogen control the balance of histone 3 modifications targeting MAGE-A3 in pituitary neoplasia. Zhu X, et al. Clin Cancer Res, 2008 Apr 1. PMID 18381936
  5. Expression of the melanoma-associated antigen is associated with progression of human thyroid cancer. Cheng S, et al. Endocr Relat Cancer, 2009 Jun. PMID 19261683

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAGE-A3 regulates tumor stemness in gastric cancer through the PI3K/AKT pathway.
    Title: MAGE-A3 regulates tumor stemness in gastric cancer through the PI3K/AKT pathway.
  2. MAGEA3 serves as an independent indicator for predicting the prognosis of ESCC.
    Title: MAGEA3 serves as an independent indicator for predicting the prognosis of ESCC.
  3. Re-examination of MAGE-A3 as a T-cell Therapeutic Target.
    Title: Re-examination of MAGE-A3 as a T-cell Therapeutic Target.
  4. Transcriptomic characterization of cancer-testis antigens identifies MAGEA3 as a driver of tumor progression in hepatocellular carcinoma.
    Title: Transcriptomic characterization of cancer-testis antigens identifies MAGEA3 as a driver of tumor progression in hepatocellular carcinoma.
  5. IGF2BP1 is the first positive marker for anaplastic thyroid carcinoma diagnosis.
    Title: IGF2BP1 is the first positive marker for anaplastic thyroid carcinoma diagnosis.
  6. Immunological and functional aspects of MAGEA3 cancer/testis antigen.
    Title: Immunological and functional aspects of MAGEA3 cancer/testis antigen.
  7. Nuclear overexpression levels of MAGE-A3 predict poor prognosis in patients with prostate cancer.
    Title: Nuclear overexpression levels of MAGE-A3 predict poor prognosis in patients with prostate cancer.
  8. LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma progression by regulating MAGEA3 and DCAF4L2 expression.
    Title: LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma progression by regulating MAGEA3 and DCAF4L2 expression.
  9. MAGE-A3 is a prognostic biomarker for poor clinical outcome in cutaneous squamous cell carcinoma with perineural invasion via modulation of cell proliferation.
    Title: MAGE-A3 is a prognostic biomarker for poor clinical outcome in cutaneous squamous cell carcinoma with perineural invasion via modulation of cell proliferation.
  10. Aberrantly enhanced melanoma-associated antigen (MAGE)-A3 expression facilitates cervical cancer cell proliferation and metastasis via actuating Wnt signaling pathway.
    Title: Aberrantly enhanced melanoma-associated antigen (MAGE)-A3 expression facilitates cervical cancer cell proliferation and metastasis via actuating Wnt signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (76)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of melanoma antigen family A, 3 (MAGEA3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC14613

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables caspase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
melanoma-associated antigen 3
Names
MAGE-3 antigen
antigen MZ2-D
cancer/testis antigen 1.3
cancer/testis antigen family 1, member 3
melanoma antigen family A, 3
melanoma antigen family A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013244.2 RefSeqGene

    Range
    5002..8555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005362.4 → NP_005353.1  melanoma-associated antigen 3

    See identical proteins and their annotated locations for NP_005353.1

    Status: REVIEWED

    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS76045.1
    UniProtKB/Swiss-Prot
    P43357, Q6FHI6
    UniProtKB/TrEMBL
    Q53EX0
    Related
    ENSP00000359301.3, ENST00000370278.4
    Conserved Domains (2) summary
    pfam01454
    Location:116 → 280
    MAGE; MAGE family
    pfam12440
    Location:5 → 94
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    152698794..152702347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724818.3 → XP_006724881.1  melanoma-associated antigen 3 isoform X1

    See identical proteins and their annotated locations for XP_006724881.1

    UniProtKB/Swiss-Prot
    P43357, Q6FHI6
    UniProtKB/TrEMBL
    Q53EX0
    Conserved Domains (2) summary
    pfam01454
    Location:116 → 280
    MAGE; MAGE family
    pfam12440
    Location:5 → 94
    MAGE_N; Melanoma associated antigen family N terminal

  2. XM_011531160.4 → XP_011529462.1  melanoma-associated antigen 3 isoform X1

    See identical proteins and their annotated locations for XP_011529462.1

    UniProtKB/Swiss-Prot
    P43357, Q6FHI6
    UniProtKB/TrEMBL
    Q53EX0
    Conserved Domains (2) summary
    pfam01454
    Location:116 → 280
    MAGE; MAGE family
    pfam12440
    Location:5 → 94
    MAGE_N; Melanoma associated antigen family N terminal

  3. XM_005274676.4 → XP_005274733.1  melanoma-associated antigen 3 isoform X1

    See identical proteins and their annotated locations for XP_005274733.1

    UniProtKB/Swiss-Prot
    P43357, Q6FHI6
    UniProtKB/TrEMBL
    Q53EX0
    Related
    ENSP00000473093.1, ENST00000598245.2
    Conserved Domains (2) summary
    pfam01454
    Location:116 → 280
    MAGE; MAGE family
    pfam12440
    Location:5 → 94
    MAGE_N; Melanoma associated antigen family N terminal

  4. XM_011531161.2 → XP_011529463.1  melanoma-associated antigen 3 isoform X1

    See identical proteins and their annotated locations for XP_011529463.1

    UniProtKB/Swiss-Prot
    P43357, Q6FHI6
    UniProtKB/TrEMBL
    Q53EX0
    Conserved Domains (2) summary
    pfam01454
    Location:116 → 280
    MAGE; MAGE family
    pfam12440
    Location:5 → 94
    MAGE_N; Melanoma associated antigen family N terminal

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791818.1 Reference GRCh38.p14 PATCHES

    Range
    381298..384860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333339.1 → XP_054189314.1  melanoma-associated antigen 3 isoform X1

    UniProtKB/Swiss-Prot
    P43357, Q6FHI6

  2. XM_054333338.1 → XP_054189313.1  melanoma-associated antigen 3 isoform X1

    UniProtKB/Swiss-Prot
    P43357, Q6FHI6

  3. XM_054333337.1 → XP_054189312.1  melanoma-associated antigen 3 isoform X1

    UniProtKB/Swiss-Prot
    P43357, Q6FHI6

  4. XM_054333340.1 → XP_054189315.1  melanoma-associated antigen 3 isoform X1

    UniProtKB/Swiss-Prot
    P43357, Q6FHI6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    150965367..150968920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327057.1 → XP_054183032.1  melanoma-associated antigen 3 isoform X1

    UniProtKB/Swiss-Prot
    A8IF93, P43360, Q6NW44
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43357.1 GenPept UniProtKB/Swiss-Prot:P43357

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