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MAGEA6 MAGE family member A6 [ Homo sapiens (human) ]

Gene ID: 4105, updated on 2-Nov-2024

Summary

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Official Symbol
MAGEA6provided by HGNC
Official Full Name
MAGE family member A6provided by HGNC
Primary source
HGNC:HGNC:6804
See related
Ensembl:ENSG00000197172 MIM:300176; AllianceGenome:HGNC:6804
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT1.6; MAGE6; MAGE3B; MAGE-3b
Summary
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Restricted expression toward testis (RPKM 6.4) See more
Orthologs
all
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Genomic context

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See MAGEA6 in Genome Data Viewer
Location:
Xq28
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (152766136..152769689, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151032689..151036258, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151934652..151938198, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGE family member A2 Neighboring gene CSAG family member 3 Neighboring gene MAGEA6 divergent transcript Neighboring gene MAGE family member A4 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:151987738-151988937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21058 Neighboring gene centrin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression. Tsang YH, et al. Elife, 2020 Apr 9. PMID 32270762, Free PMC Article
  2. Knockdown of MAGE-A6 enhanced the irradiation sensitivity of non-small cell lung cancer cells by activating the AMPK pathway. Zhou J, et al. Environ Toxicol, 2022 Jul. PMID 35285568
  3. Tissue Expression of Melanoma-associated Antigen A6 and Clinical Characteristics of Gastric Cancer. Endo M, et al. Anticancer Res, 2019 Nov. PMID 31704814
  4. Knockdown of MAGEA6 Activates AMP-Activated Protein Kinase (AMPK) Signaling to Inhibit Human Renal Cell Carcinoma Cells. Ye X, et al. Cell Physiol Biochem, 2018. PMID 29448247
  5. A Comprehensive Expression Analysis of Cancer Testis Antigens in Head and Neck Squamous Cell Carcinoma Revels MAGEA3/6 as a Marker for Recurrence. Zamunér FT, et al. Mol Cancer Ther, 2015 Mar. PMID 25564441

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of MAGE-A6 enhanced the irradiation sensitivity of non-small cell lung cancer cells by activating the AMPK pathway.
    Title: Knockdown of MAGE-A6 enhanced the irradiation sensitivity of non-small cell lung cancer cells by activating the AMPK pathway.
  2. Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer.
    Title: Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer.
  3. Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression.
    Title: Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression.
  4. Lnc-THOR silencing inhibits human glioma cell survival by activating MAGEA6-AMPK signaling.
    Title: Lnc-THOR silencing inhibits human glioma cell survival by activating MAGEA6-AMPK signaling.
  5. data indicate that the activation of CT-GABRA3 is correlated with that of MAGEA6. Therefore, MAGEA6 is linked with CT-GABRA3 through a bidirectional promoter.
    Title: Epigenetic Coactivation of MAGEA6 and CT-GABRA3 Defines Orientation of a Segmental Duplication in the Human X Chromosome.
  6. High MAGEA6 expression is associated with recurrence in Gastric Cancer.
    Title: Tissue Expression of Melanoma-associated Antigen A6 and Clinical Characteristics of Gastric Cancer.
  7. Data indicate that miR-1273g represses melanoma antigen family A 3/melanoma antigen family A 6 (MAGEA3/6 )expression in colorectal cancer (CRC) cells and tissues, which may suggest a cancer-specific therapeutic.
    Title: miR-1273g silences MAGEA3/6 to inhibit human colorectal cancer cell growth via activation of AMPK signaling.
  8. MAGEA6 knockdown by targeted-shRNA induced AMPK stabilization and activation, which led to mTOR complex 1 (mTORC1) in-activation and RCC cell death/apoptosis.
    Title: Knockdown of MAGEA6 Activates AMP-Activated Protein Kinase (AMPK) Signaling to Inhibit Human Renal Cell Carcinoma Cells.
  9. MAGEA6 promotes glioma cell survival possibly via targeting AMPKalpha1.
    Title: MAGEA6 promotes human glioma cell survival via targeting AMPKα1.
  10. MageA6 and MageA11 form a protein complex resulting in the stabilization of MageA11 and consequently the enhancement of androgen receptor activity.
    Title: Functional interaction between co-expressed MAGE-A proteins.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of melanoma antigen family A, 6 (MAGEA6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC52297

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
melanoma-associated antigen 6
Names
MAGE-6 antigen
MAGE3B antigen
cancer/testis antigen 1.6
cancer/testis antigen family 1, member 6
melanoma antigen family A, 6
melanoma antigen family A6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005363.5 → NP_005354.1  melanoma-associated antigen 6

    See identical proteins and their annotated locations for NP_005354.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS76050.1
    UniProtKB/Swiss-Prot
    A8IF93, P43360, Q6NW44
    UniProtKB/TrEMBL
    Q6FGT7, Q6FHI5
    Related
    ENSP00000329199.5, ENST00000329342.10
    Conserved Domains (2) summary
    pfam01454
    Location:116 → 280
    MAGE; MAGE family
    pfam12440
    Location:5 → 94
    MAGE_N; Melanoma associated antigen family N terminal

  2. NM_175868.4 → NP_787064.1  melanoma-associated antigen 6

    See identical proteins and their annotated locations for NP_787064.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS76050.1
    UniProtKB/Swiss-Prot
    A8IF93, P43360, Q6NW44
    UniProtKB/TrEMBL
    Q6FGT7, Q6FHI5
    Related
    ENSP00000480637.1, ENST00000616035.4
    Conserved Domains (2) summary
    pfam01454
    Location:116 → 280
    MAGE; MAGE family
    pfam12440
    Location:5 → 94
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    152766136..152769689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791818.1 Reference GRCh38.p14 PATCHES

    Range
    313913..317471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333342.1 → XP_054189317.1  melanoma-associated antigen 6 isoform X1

    UniProtKB/Swiss-Prot
    A8IF93, P43360, Q6NW44

  2. XM_054333341.1 → XP_054189316.1  melanoma-associated antigen 6 isoform X1

    UniProtKB/Swiss-Prot
    A8IF93, P43360, Q6NW44

  3. XM_054333343.1 → XP_054189318.1  melanoma-associated antigen 6 isoform X1

    UniProtKB/Swiss-Prot
    A8IF93, P43360, Q6NW44

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    151032689..151036258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327060.1 → XP_054183035.1  melanoma-associated antigen 6 isoform X1

    UniProtKB/Swiss-Prot
    P43357, Q6FHI6

  2. XM_054327059.1 → XP_054183034.1  melanoma-associated antigen 6 isoform X1

    UniProtKB/Swiss-Prot
    P43357, Q6FHI6

  3. XM_054327061.1 → XP_054183036.1  melanoma-associated antigen 6 isoform X1

    UniProtKB/Swiss-Prot
    P43357, Q6FHI6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43360.1 GenPept UniProtKB/Swiss-Prot:P43360

Gene LinkOut

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