PGRP-LB Peptidoglycan recognition protein LB [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PGRP-LBprovided by FlyBase
Official Full Name: Peptidoglycan recognition protein LBprovided by FlyBase
Primary source: FLYBASE:FBgn0037906
Locus tag: Dmel_CG14704
See related: AllianceGenome:FB:FBgn0037906
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14704; Dmel\CG14704; PGRP; pgrp-lb; pgrp-LB
Summary: Enables N-acetylmuramoyl-L-alanine amidase activity. Involved in defense response to Gram-positive bacterium; negative regulation of defense response to bacterium; and peptidoglycan catabolic process. Located in extracellular region. Is expressed in several structures, including adult fat body; adult head; adult oenocyte; embryonic/larval gut; and embryonic/larval proventriculus. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 86E6-86E6; 3-51 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (11452849..11460552, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (7278571..7286274, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disparate regulation of IMD signaling drives sex differences in infection pathology in Drosophila melanogaster.
Title: Disparate regulation of IMD signaling drives sex differences in infection pathology in Drosophila melanogaster.
PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction.
Title: PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction.
The data show that the PGRP-LB locus can produce cytosolic and extracellular proteins that both buffer the effects of gut-bacteria-derived Peptidoglycan.
Title: Cytosolic and Secreted Peptidoglycan-Degrading Enzymes in Drosophila Respectively Control Local and Systemic Immune Responses to Microbiota.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables N-acetylmuramoyl-L-alanine amidase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetylmuramoyl-L-alanine amidase activity	IEA Inferred from Electronic Annotation more info
enables N-acetylmuramoyl-L-alanine amidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables peptidoglycan binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidoglycan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in peptidoglycan catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in peptidoglycan catabolic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peptidoglycan recognition protein LB

Names: CG14704-PA; CG14704-PB; CG14704-PC; CG14704-PD; CG14704-PE; CG14704-PF; PGRP-LB-PA; PGRP-LB-PB; PGRP-LB-PC; PGRP-LB-PD; PGRP-LB-PE; PGRP-LB-PF; Peptidoglycan-recognition protein-LB precursor

NP_001247052.1

EC 3.5.1.28

NP_001247053.1

EC 3.5.1.28

NP_001247054.1

EC 3.5.1.28

NP_650079.1

EC 3.5.1.28

NP_731575.1

EC 3.5.1.28

NP_731576.1

EC 3.5.1.28

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

11452849..11460552 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260123.1 → NP_001247052.1 peptidoglycan recognition protein LB, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247052.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K741

Conserved Domains (1) summary

smart00701
Location:53 → 195

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_169392.2 → NP_731575.1 peptidoglycan recognition protein LB, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731575.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8INK6, Q9VGN3

Related

FBpp0081872

Conserved Domains (1) summary

smart00701
Location:30 → 172

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_001260124.2 → NP_001247053.1 peptidoglycan recognition protein LB, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247053.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V2P5

Conserved Domains (1) summary

smart00701
Location:13 → 155

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_169393.3 → NP_731576.1 peptidoglycan recognition protein LB, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731576.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V2P5

Related

FBpp0081873

Conserved Domains (1) summary

smart00701
Location:13 → 155

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_141822.3 → NP_650079.1 peptidoglycan recognition protein LB, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650079.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V2P5

Related

FBpp0081874

Conserved Domains (1) summary

smart00701
Location:13 → 155

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_001260125.2 → NP_001247054.1 peptidoglycan recognition protein LB, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247054.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V2P5

Conserved Domains (1) summary

smart00701
Location:13 → 155

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme