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C10orf105 chromosome 10 open reading frame 105 [ Homo sapiens (human) ]

Gene ID: 414152, updated on 5-Mar-2024

Summary

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Official Symbol
C10orf105provided by HGNC
Official Full Name
chromosome 10 open reading frame 105provided by HGNC
Primary source
HGNC:HGNC:20304
See related
Ensembl:ENSG00000214688 AllianceGenome:HGNC:20304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen (RPKM 1.7), testis (RPKM 0.9) and 19 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
10q22.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (71711701..71737850, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (72582515..72608664, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73471458..73497607, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cadherin related 23 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73277285-73277785 Neighboring gene CDH23 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73287079-73287589 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73295035-73295856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73300575-73301272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73301937-73302516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73303768-73304277 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:73307302-73307496 Neighboring gene uncharacterized LOC105378355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73321825-73322348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73322349-73322872 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:73327348-73328169 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:73331571-73332072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73372049-73372563 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73381965-73382568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73390204-73391034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73392929-73393464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73393465-73394000 Neighboring gene Sharpr-MPRA regulatory region 11817 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:73398641-73399578 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:73402475-73403119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3515 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:73417087-73417810 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73417811-73418534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73447088-73447602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3517 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73460453-73461367 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73461368-73462281 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:73476810-73477007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73478924-73479672 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:73485282-73486481 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:73489247-73489438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73517352-73517887 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:73526094-73527293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2466 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:73537763-73537918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73550045-73550944 Neighboring gene V-set immunoregulatory receptor Neighboring gene microRNA 7152

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors. Feng X, et al. Sci Adv, 2022 May 13. PMID 35559673, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00245

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein C10orf105

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164375.3 → NP_001157847.1  uncharacterized protein C10orf105

    See identical proteins and their annotated locations for NP_001157847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL731541, BC071608
    Consensus CDS
    CCDS44430.1
    UniProtKB/Swiss-Prot
    Q8TEF2
    Related
    ENSP00000403151.2, ENST00000441508.4

  2. NM_001168390.2 → NP_001161862.1  uncharacterized protein C10orf105

    See identical proteins and their annotated locations for NP_001161862.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK074172, AL731541
    Consensus CDS
    CCDS44430.1
    UniProtKB/Swiss-Prot
    Q8TEF2
    Related
    ENSP00000381766.3, ENST00000398786.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    71711701..71737850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    72582515..72608664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TEF2.3 GenPept UniProtKB/Swiss-Prot:Q8TEF2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Research Materials
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