U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

COX5A Cytochrome c oxidase subunit 5A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41432, updated on 14-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
COX5Aprovided by FlyBase
Official Full Name
Cytochrome c oxidase subunit 5Aprovided by FlyBase
Primary source
FLYBASE:FBgn0019624
Locus tag
Dmel_CG14724
See related
AllianceGenome:FB:FBgn0019624
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14724; cova; CoVa; COX; COX-5A; cox5A; Cox5a; COX5a; COXA; COXA_DROME; Dmel\CG14724; mito; Q94514; tend; Va
Summary
Involved in positive regulation of cell cycle. Located in mitochondrion. Is expressed in adult head; adult heart; organism; and spermatozoon. Used to study cytochrome-c oxidase deficiency disease. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 20. Orthologous to human COX5A (cytochrome c oxidase subunit 5A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See COX5A in Genome Data Viewer
Location:
86F9-86F9; 3-51 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11819359..11820299)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7645081..7646021)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Histamine-gated chloride channel subunit 1 Neighboring gene SET domain binding factor Neighboring gene Chloride channel-a Neighboring gene glorund Neighboring gene Kynurenine aminotransferase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Analysis of mitochondrial organization and function in the Drosophila blastoderm embryo. Chowdhary S, et al. Sci Rep, 2017 Jul 14. PMID 28710464, Free PMC Article
  2. Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant. Hill JH, et al. Nat Genet, 2014 Apr. PMID 24614072, Free PMC Article
  3. Mitochondrial dynamics regulates Drosophila intestinal stem cell differentiation. Deng H, et al. Cell Death Discov, 2018. PMID 30062062, Free PMC Article
  4. Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster. Ferguson M, et al. Biochem J, 2005 Sep 1. PMID 15853766, Free PMC Article
  5. Glorund, a Drosophila hnRNP F/H homolog, is an ovarian repressor of nanos translation. Kalifa Y, et al. Dev Cell, 2006 Mar. PMID 16516833

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cytochrome c oxidase subunit 5A
Names
CG14724-PA
CG14724-PB
CG14724-PC
CG14724-PD
COX5A-PA
COX5A-PB
COX5A-PC
COX5A-PD
complex IV
cytochrome c oxidase
cytochrome c oxidase Va
cytochrome c oxidase Va, mt precursor
cytochrome c oxidase polypeptide Va
cytochrome c oxidase subunit Va
cytochrome c oxidase subunit Va preprotein
cytochrome oxidase Va
cytochrome oxidase subunit Va
cytochrome-c oxidase subunit Va
subunit 5A
subunit Va
subunit Va of complex IV
tenured

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11819359..11820299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057869.4 → NP_477217.1  cytochrome c oxidase subunit 5A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477217.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53XG7, Q94514, Q9VGH4
    UniProtKB/TrEMBL
    A0A0B4KFT0
    Related
    FBpp0081947
    Conserved Domains (1) summary
    cd00923
    Location:33 → 136
    Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. NM_169436.3 → NP_731641.1  cytochrome c oxidase subunit 5A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731641.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53XG7, Q94514, Q9VGH4
    UniProtKB/TrEMBL
    A0A0B4KFT0
    Related
    FBpp0081948
    Conserved Domains (1) summary
    cd00923
    Location:33 → 136
    Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  3. NM_001316557.1 → NP_001303486.1  cytochrome c oxidase subunit 5A, isoform D [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53XG7, Q94514, Q9VGH4
    UniProtKB/TrEMBL
    A0A0B4KFT0
    Conserved Domains (1) summary
    cd00923
    Location:33 → 136
    Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  4. NM_001275559.1 → NP_001262488.1  cytochrome c oxidase subunit 5A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262488.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53XG7, Q94514, Q9VGH4
    UniProtKB/TrEMBL
    A0A0B4KFT0
    Conserved Domains (1) summary
    cd00923
    Location:33 → 136
    Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFT0 A0A0B4KFT0
Q94514.2 Q94514

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous