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nhr-27 Nuclear hormone receptor family member nhr-27 [ Caenorhabditis elegans ]

Gene ID: 41656994, updated on 2-Nov-2024

Summary

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Official Symbol
nhr-27
Official Full Name
Nuclear hormone receptor family member nhr-27
Primary source
WormBase:WBGene00008901
Locus tag
CELE_F16H9.2
See related
AllianceGenome:WB:WBGene00008901
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in determination of adult lifespan. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-27 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (12705624..12808318, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Nuclear Hormone Receptor family Neighboring gene Nuclear Hormone Receptor family Neighboring gene ncRNA Neighboring gene RGS domain-containing protein;Regulator of G-protein signaling rgs-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene P-GlycoProtein related Neighboring gene P-GlycoProtein related Neighboring gene P-glycoprotein 14 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Choline/ethanolaminephosphotransferase 1-like Neighboring gene Interleukin cytokine-related protein 17.1 Neighboring gene Glutamate 5-kinase Neighboring gene Seven TM Receptor Neighboring gene Seven TM Receptor Neighboring gene AntiBacterial Factor related Neighboring gene AntiBacterial Factor related Neighboring gene HMG box domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants. Khan MH, et al. Aging (Albany NY), 2013 Oct. PMID 24107417, Free PMC Article
  2. PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. Svensk E, et al. PLoS Genet, 2013. PMID 24068966, Free PMC Article
  3. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
  4. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear hormone receptor family member nhr-27
NP_001257197.1
  • Confirmed by transcript evidence
NP_001366722.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    12705624..12808318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381126.1 → NP_001366722.1  Nuclear hormone receptor family member nhr-27 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    smart00399
    Location:7 → 76
    ZnF_C4; c4 zinc finger in nuclear hormone receptors
    smart00430
    Location:140 → 302
    HOLI; Ligand binding domain of hormone receptors

  2. NM_001270268.1 → NP_001257197.1  Nuclear hormone receptor family member nhr-27 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257197.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGN8, Q19500
    Conserved Domains (2) summary
    smart00399
    Location:26 → 95
    ZnF_C4; c4 zinc finger in nuclear hormone receptors
    smart00430
    Location:159 → 321
    HOLI; Ligand binding domain of hormone receptors
Nucleotide Protein
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