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SerRS-m Seryl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41862, updated on 2-Nov-2024

Summary

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Official Symbol
SerRS-mprovided by FlyBase
Official Full Name
Seryl-tRNA synthetase, mitochondrialprovided by FlyBase
Primary source
FLYBASE:FBgn0021750
Locus tag
Dmel_CG4938
See related
AllianceGenome:FB:FBgn0021750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Aat-Ser; Aats-ser; CG4938; Dmel\CG4938; DmSerRS2; DmSRS2; dSARS; SerRS; SerRS2; SRS
Summary
Contributes to serine-tRNA ligase activity. Involved in mitochondrial seryl-tRNA aminoacylation. Part of serine-tRNA ligase complex. Is expressed in embryonic/larval salivary gland and organism. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See SerRS-m in Genome Data Viewer
Location:
88F1-88F1; 3-57 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15340667..15343218)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11166389..11168940)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene FK506-binding protein 39kD Neighboring gene Cytoplasmic FMR1 interacting protein Neighboring gene N-acetylglucosamine kinase Neighboring gene Surfeit 4 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein-Protein Interactions of Seryl-tRNA Synthetases with Emphasis on Human Counterparts and Their Connection to Health and Disease. Dulic M, et al. Life (Basel), 2024 Jan 15. PMID 38255739, Free PMC Article
  2. New aminoacyl-tRNA synthetase-like protein in insecta with an essential mitochondrial function. Guitart T, et al. J Biol Chem, 2010 Dec 3. PMID 20870726, Free PMC Article
  3. Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit. Picchioni D, et al. Cell Rep, 2019 Apr 2. PMID 30943413
  4. Selenium metabolism in Drosophila. Characterization of the selenocysteine tRNA population. Zhou X, et al. J Biol Chem, 1999 Jun 25. PMID 10373487
  5. Surfeit locus gene homologs are widely distributed in invertebrate genomes. Armes N, et al. Mol Cell Biol, 1996 Oct. PMID 8816471, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to serine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-tRNA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables serine-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial seryl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial seryl-tRNA aminoacylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in seryl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in seryl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion TAS
Traceable Author Statement
more info
 PubMed 
part_of serine-tRNA ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Seryl-tRNA synthetase, mitochondrial
Names
CG4938-PA
CG4938-PB
SerRS-m-PA
SerRS-m-PB
seryl-tRNA synthetase
NP_001262599.1
NP_524365.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15340667..15343218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275670.1 → NP_001262599.1  Seryl-tRNA synthetase, mitochondrial, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262599.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VF85
    Conserved Domains (2) summary
    COG0172
    Location:60 → 404
    SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cl00268
    Location:100 → 394
    class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

  2. NM_079641.3 → NP_524365.1  Seryl-tRNA synthetase, mitochondrial, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524365.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VF85
    Related
    FBpp0082542
    Conserved Domains (2) summary
    COG0172
    Location:60 → 404
    SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cl00268
    Location:100 → 394
    class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18406 O18406
Q9VF85 Q9VF85

Gene LinkOut

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