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Nagk N-acetylglucosamine kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41863, updated on 2-Nov-2024

Summary

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Official Symbol
Nagkprovided by FlyBase
Official Full Name
N-acetylglucosamine kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0038321
Locus tag
Dmel_CG6218
See related
AllianceGenome:FB:FBgn0038321
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6218; Dmel\CG6218; DNagk
Summary
Predicted to enable N-acetylglucosamine kinase activity. Predicted to be involved in N-acetylglucosamine catabolic process; UDP-N-acetylglucosamine biosynthetic process; and carbohydrate phosphorylation. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval lateral glial cell; ganglia; and primary tracheal branch. Orthologous to human NAGK (N-acetylglucosamine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Nagk in Genome Data Viewer
Location:
88F1-88F1; 3-57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15337908..15343256, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11163630..11168978, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene easter Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene FK506-binding protein 39kD Neighboring gene Cytoplasmic FMR1 interacting protein Neighboring gene Seryl-tRNA synthetase, mitochondrial Neighboring gene Surfeit 4 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway. Neitzel LR, et al. Mech Dev, 2019 Apr. PMID 30904594, Free PMC Article
  2. An endogenous small interfering RNA pathway in Drosophila. Czech B, et al. Nature, 2008 Jun 5. PMID 18463631, Free PMC Article
  3. Subtypes of glial cells in the Drosophila embryonic ventral nerve cord as related to lineage and gene expression. Beckervordersandforth RM, et al. Mech Dev, 2008 May-Jun. PMID 18296030
  4. The early life of a fly glial cell. Altenhein B, et al. Wiley Interdiscip Rev Dev Biol, 2016 Jan-Feb. PMID 26224590
  5. Translational profiling of clock cells reveals circadianly synchronized protein synthesis. Huang Y, et al. PLoS Biol, 2013 Nov. PMID 24348200, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N-acetylglucosamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylglucosamine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acetylglucosamine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in N-acetylglucosamine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in UDP-N-acetylglucosamine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in carbohydrate phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
N-acetylglucosamine kinase
Names
CG6218-PA
CG6218-PB
Nagk-PA
Nagk-PB
NP_001262598.1
NP_650448.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15337908..15343256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142191.1 → NP_650448.1  N-acetylglucosamine kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650448.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VF86
    Related
    FBpp0082573, FBtr0083119
    Conserved Domains (1) summary
    cl17037
    Location:1 → 285
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. NM_001275669.1 → NP_001262598.1  N-acetylglucosamine kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262598.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VF86
    Conserved Domains (1) summary
    cl17037
    Location:1 → 285
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VF86 Q9VF86

Gene LinkOut

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